Hydrocortamate HCl | CAS#125-03-1 | Anti-inflammatory glucocorticoid

MedKoo Cat#: 317997 | Name: Hydrocortamate HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydrocortamate HCl is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation due to corticosteroid-responsive dermatoses.

Chemical Structure

Hydrocortamate HCl

CAS#125-03-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 317997

Name: Hydrocortamate HCl

CAS#: 125-03-1 (HCl)

Chemical Formula: C27H42ClNO6

Exact Mass:

Molecular Weight: 512.08

Elemental Analysis: C, 63.33; H, 8.27; Cl, 6.92; N, 2.74; O, 18.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

125-03-1 (HCl) 76-47-1 (free base)

Synonym

Hydrocortamate Hydrochloride; Ethamicort; Ulcort; Magnacort; Hydrocortamate HCl; UNII-9QM8U7R83W;

IUPAC/Chemical Name

[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2-(diethylamino)acetate;hydrochloride

InChi Key

AKQNAIYKSALPKV-OYHXESGYSA-N

InChi Code

InChI=1S/C27H41NO6.ClH/c1-5-28(6-2)15-23(32)34-16-22(31)27(33)12-10-20-19-8-7-17-13-18(29)9-11-25(17,3)24(19)21(30)14-26(20,27)4;/h13,19-21,24,30,33H,5-12,14-16H2,1-4H3;1H/t19-,20-,21-,24+,25-,26-,27-;/m0./s1

SMILES Code

CCN(CC)CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO, not in water	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 512.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: ROBINSON HM Jr, ROBINSON RC, STRAHAN JF. The treatment of dermatoses with a new steroid (ethamicort). Antibiotic Med Clin Ther (New York). 1956 Dec;3(7):461-5. PubMed PMID: 13373315. 2: GORDILLO HERNANDEZ D. [Use of a new topical steroid (ethamicort) in allergic dermatitis]. Medicina (Mex). 1958 Nov 10;38(807):510-5. Spanish. PubMed PMID: 13599880. 3: HOWELL CM Jr. Use of a topical water soluble steroid (ethamicort) in dermatoses. Am Pract Dig Treat. 1957 Dec;8(12):1928-9. PubMed PMID: 13487987.