Synonym
Apresolin, Apressin, Aprezolin, Hydralazine
IUPAC/Chemical Name
1-Hydrazinophthalazine
InChi Key
RPTUSVTUFVMDQK-UHFFFAOYSA-N
InChi Code
1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
SMILES Code
c\12c(cn[nH]c1=N/N)cccc2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
160.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nyolczas N, Dékány M, Muk B, Szabó B. Combination of Hydralazine and Isosorbide-Dinitrate in the Treatment of Patients with Heart Failure with Reduced Ejection Fraction. Adv Exp Med Biol. 2018;1067:31-45. doi: 10.1007/5584_2017_112. Review. PubMed PMID: 29086392.
2: Yao L, Wu YT, Tian GX, Xia CQ, Zhang F, Zhang W. Acrolein Scavenger Hydralazine Prevents Streptozotocin-Induced Painful Diabetic Neuropathy and Spinal Neuroinflammation in Rats. Anat Rec (Hoboken). 2017 Oct;300(10):1858-1864. doi: 10.1002/ar.23618. Epub 2017 Jul 25. PubMed PMID: 28598552.
3: Chatard M, Puech C, Roche F, Perek N. Hypoxic Stress Induced by Hydralazine Leads to a Loss of Blood-Brain Barrier Integrity and an Increase in Efflux Transporter Activity. PLoS One. 2016 Jun 23;11(6):e0158010. doi: 10.1371/journal.pone.0158010. eCollection 2016. PubMed PMID: 27337093; PubMed Central PMCID: PMC4919080.
4: Flynn JT, Bradford MC, Harvey EM. Intravenous Hydralazine in Hospitalized Children and Adolescents with Hypertension. J Pediatr. 2016 Jan;168:88-92. doi: 10.1016/j.jpeds.2015.07.070. Epub 2015 Sep 1. PubMed PMID: 26340877.
5: Harati H, Rahmani M, Taghizadeh S. Acute Cholestatic Liver Injury From Hydralazine Intake. Am J Ther. 2016 Sep-Oct;23(5):e1211-4. doi: 10.1097/MJT.0000000000000310. PubMed PMID: 26291593.
6: Ostrye J, Hailpern SM, Jones J, Egan B, Chessman K, Shatat IF. The efficacy and safety of intravenous hydralazine for the treatment of hypertension in the hospitalized child. Pediatr Nephrol. 2014 Aug;29(8):1403-9. doi: 10.1007/s00467-014-2772-0. Epub 2014 Feb 20. PubMed PMID: 24554119.
