Oleandomycin is a macrolide antibiotic produced by Streptomyces antibioticus, structurally related to erythromycin. It exerts its antibacterial effect by binding to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis. Oleandomycin shows activity mainly against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes, with minimum inhibitory concentrations (MICs) typically in the range of 0.25–4 µg/mL, though its potency is generally lower than erythromycin. Due to its relatively narrow spectrum and the emergence of resistant strains, it is now rarely used alone but was historically combined with tetracycline in the product Sigmamycine to broaden antibacterial coverage.
MedKoo Cat#: 574483
Name: Oleandomycin phosphate
CAS#: 7060-74-4 (phosphate)
Chemical Formula: C35H64NO16P
Exact Mass: 785.3963
Molecular Weight: 785.86
Elemental Analysis: C, 53.49; H, 8.21; N, 1.78; O, 32.57; P, 3.94
The following data is based on the product molecular weight 785.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
