TAH-19 is a novel potent p53-MDM2/X antagonist, inhibiting MDM2 potently with a Ki value of 58 nmol/L, inducing accumulation of p53, p21 and MDM2, inhibiting cell cycle progression of U-2 OS cells at G1 phase in a p53-dependent manner.
MedKoo Cat#: 533709
Name: TAH-19
CAS#: N/A
Chemical Formula: C35H33Cl2FN4O5
Exact Mass: 678.1812
Molecular Weight: 679.57
Elemental Analysis: C, 61.86; H, 4.89; Cl, 10.43; F, 2.80; N, 8.24; O, 11.77
The following data is based on the product molecular weight 679.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
