MedKoo Cat#: 462353 | Name: TAB29

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC50 of 874 nM. It possesses therapeutic potential for human cancers.

Chemical Structure

TAB29
TAB29
CAS#2361144-71-8

Theoretical Analysis

MedKoo Cat#: 462353

Name: TAB29

CAS#: 2361144-71-8

Chemical Formula: C28H22O3

Exact Mass: 406.1569

Molecular Weight: 406.48

Elemental Analysis: C, 82.74; H, 5.46; O, 11.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TAB29; TAB-29; TAB 29
IUPAC/Chemical Name
4,6-bis(benzyloxy)-3-phenylbenzofuran
InChi Key
JDNZULXLMHWPAY-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H22O3/c1-4-10-21(11-5-1)18-29-24-16-26(30-19-22-12-6-2-7-13-22)28-25(20-31-27(28)17-24)23-14-8-3-9-15-23/h1-17,20H,18-19H2
SMILES Code
C1(OCC2=CC=CC=C2)=CC(OCC3=CC=CC=C3)=C4C(OC=C4C5=CC=CC=C5)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 406.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fan X, He H, Li J, et al. Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis. Bioorg Med Chem. 2019;27(11):2235-2244. doi:10.1016/j.bmc.2019.04.028