MedKoo Cat#: 466018 | Name: MU1656

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MU1656 is Highly Selective Inhibitor of Methyltransferase DOT1L (IC50 = 2 nM), and carbocyclic C-nucleoside analogues of the natural nucleoside derivative EPZ004777. MU1656 can potently and selectively inhibit DOT1L in vitro as well as in the cell.

Chemical Structure

MU1656
MU1656
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466018

Name: MU1656

CAS#: unknown

Chemical Formula: C32H45N7O2

Exact Mass: 559.3635

Molecular Weight: 559.76

Elemental Analysis: C, 68.66; H, 8.10; N, 17.52; O, 5.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MU1656; MU 1656; MU-1656;
IUPAC/Chemical Name
(1R,2S,3S,5R)-3-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)cyclopentane-1,2-diol
InChi Key
RKRUMZCAPLOLQM-JOMNVXSOSA-N
InChi Code
InChI=1S/C32H45N7O2/c1-18(2)38(16-20-14-23(30(41)29(20)40)26-9-10-27-31(33)34-17-35-39(26)27)22-12-19(13-22)6-11-28-36-24-8-7-21(32(3,4)5)15-25(24)37-28/h7-10,15,17-20,22-23,29-30,40-41H,6,11-14,16H2,1-5H3,(H,36,37)(H2,33,34,35)/t19-,20-,22+,23+,29-,30+/m1/s1
SMILES Code
CC(C)(C)C(C=C1)=CC2=C1NC(CC[C@H]3C[C@@H](N(C(C)C)C[C@@H]4[C@@H](O)[C@@H](O)[C@H](C5=CC=C6N5N=CN=C6N)C4)C3)=N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 559.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Khirsariya P, Pospíšil P, Maier L, Boudný M, Babáš M, Kroutil O, Mráz M, Vácha R, Paruch K. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Mar 18. doi: 10.1021/acs.jmedchem.1c02228. Epub ahead of print. PMID: 35302777.