FCE-22807 | CAS# 86756-45-8 | Biochemical

MedKoo Cat#: 575336 | Name: FCE-22807

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FCE-22807 is a long-acting rifamycin antibiotic. Rifamycins are particularly effective against mycobacteria, and are therefore used to treat tuberculosis, leprosy, and mycobacterium avium complex (MAC) infections.

Chemical Structure

FCE-22807

CAS#86756-45-8

Theoretical Analysis

MedKoo Cat#: 575336

Name: FCE-22807

CAS#: 86756-45-8

Chemical Formula: C44H56N4O12

Exact Mass: 832.3895

Molecular Weight: 832.95

Elemental Analysis: C, 63.45; H, 6.78; N, 6.73; O, 23.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

FCE-22807; FCE22807; FCE 22807

IUPAC/Chemical Name

Rifamycin, 1,4-dideoxy-1,4-dihydro-1,4-dioxo-3-(((1-piperidinylmethylene)hydrazono)methyl)-

InChi Key

RYJAEZQKMOPBHP-YNTMCLQCSA-N

InChi Code

InChI=1S/C44H56N4O12/c1-22-14-13-15-23(2)43(56)47-34-29(20-45-46-21-48-17-11-10-12-18-48)38(53)31-32(39(34)54)37(52)27(6)41-33(31)42(55)44(8,60-41)58-19-16-30(57-9)24(3)40(59-28(7)49)26(5)36(51)25(4)35(22)50/h13-16,19-22,24-26,30,35-36,40,50-52H,10-12,17-18H2,1-9H3,(H,47,56)/b14-13+,19-16+,23-15-,45-20+,46-21+/t22-,24+,25+,26+,30-,35-,36+,40+,44-/m0/s1

SMILES Code

CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4C(=O)C(=C(\C=N\N=C\N5CCCCC5)C(=O)c4c3C2=O)NC(=O)\C(=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)\C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 832.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Dhillon J, Dickinson JM, Guy JA, Ng TK, Mitchison DA. Activity of two long-acting rifamycins, rifapentine and FCE 22807, in experimental murine tuberculosis. Tuber Lung Dis. 1992 Apr;73(2):116-23. doi: 10.1016/0962-8479(92)90066-S. PMID: 1643297. 2. Dickinson JM, Mitchison DA. In vitro activities against mycobacteria of two long-acting rifamycins, FCE22807 and CGP40/469A (SPA-S-565). Tubercle. 1990 Jun;71(2):109-15. doi: 10.1016/0041-3879(90)90005-s. PMID: 2120827. 3.Dhillon J, Mitchison DA. Activity in vitro of rifabutin, FCE 22807, rifapentine, and rifampin against Mycobacterium microti and M. tuberculosis and their penetration into mouse peritoneal macrophages. Am Rev Respir Dis. 1992 Jan;145(1):212-4. doi: 10.1164/ajrccm/145.1.212. PMID: 1309967.