FT001 is a potent and selective BET Bromodomain inhibitor. FT001 inhibited the expression of MYC in the submicromolar range (IC50 = 0.46 μM). FT001 has potent antiproliferative effects against MV-4-11 and demonstrates significant MYC mRNA suppression both in vitro and in vivo. Upon daily oral dosing of FT001, complete tumor growth inhibition was observed at well tolerated doses.
MedKoo Cat#: 407503
Name: FT001
CAS#: 1778655-51-8
Chemical Formula: C25H29N3O4S
Exact Mass: 467.1879
Molecular Weight: 467.58
Elemental Analysis: C, 64.22; H, 6.25; N, 8.99; O, 13.69; S, 6.86
The following data is based on the product molecular weight 467.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
