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MedKoo Cat#: 413293 | Name: Hydrocortisone probutate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydrocortisone probutate is the probutate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.

Chemical Structure

Hydrocortisone probutate
Hydrocortisone probutate
CAS#72590-77-3 (probutate)

Theoretical Analysis

MedKoo Cat#: 413293

Name: Hydrocortisone probutate

CAS#: 72590-77-3 (probutate)

Chemical Formula: C28H40O7

Exact Mass: 488.2774

Molecular Weight: 488.62

Elemental Analysis: C, 68.83; H, 8.25; O, 22.92

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
50mg USD 650.00 2 Weeks
100mg USD 850.00 2 Weeks
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Related CAS #
72590-77-3 (probutate) 57524-89-7 (valerate) 508-99-6 (cypionate) 125-04-2 (sodium succinate) 2203-97-6 (hemisuccinate anhydrous) 13609-67-1 (butyrate) 50-03-3 (Acetate) 74050-20-7 (aceponate) 50-23-7 (free base)
Synonym
Hydrocortisone probutate; TS408; TS-408; TS 408
IUPAC/Chemical Name
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate
InChi Key
FOGXJPFPZOHSQS-AYVLZSQQSA-N
InChi Code
InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1
SMILES Code
C[C@@]12[C@](C(COC(CC)=O)=O)(OC(CCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders.
In vitro activity:
TBD
In vivo activity:
Characteristics of the specific binding of hydrocortisone 17-butyrate 21-propionate (HBP) to the cytoplasmic fraction from rat liver were investigated. The inhibition constant (Ki) of HBP for the site of 3H-dexamethasone (3H-DM) binding was approximately equal to the value of DM and significantly smaller than that of hydrocortisone (HC). Reference: Jpn J Pharmacol. 1985 Feb;37(2):143-50. https://pubmed.ncbi.nlm.nih.gov/3999470/
Solvent mg/mL mM
Solubility
DMSO 250.0 511.64
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 488.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Muramatsu M, Tanaka M, Otomo S, Aihara H, Kuriyama K. Characteristics of binding of a new anti-inflammatory glucocorticoid, hydrocortisone 17-butyrate 21-propionate (HBP), to glucocorticoid receptors of rat liver. Jpn J Pharmacol. 1985 Feb;37(2):143-50. doi: 10.1254/jjp.37.143. PMID: 3999470.
In vitro protocol:
TBD
In vivo protocol:
1. Muramatsu M, Tanaka M, Otomo S, Aihara H, Kuriyama K. Characteristics of binding of a new anti-inflammatory glucocorticoid, hydrocortisone 17-butyrate 21-propionate (HBP), to glucocorticoid receptors of rat liver. Jpn J Pharmacol. 1985 Feb;37(2):143-50. doi: 10.1254/jjp.37.143. PMID: 3999470.
1: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Mar;28(2):121-42. PMID: 16636723.