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MedKoo Cat#: 571289 | Name: Hydrocortisone hemisuccinate anhydrous
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydrocortisone hemisuccinate anhydrous is an anti-inflammatory agent.

Chemical Structure

Hydrocortisone hemisuccinate anhydrous
Hydrocortisone hemisuccinate anhydrous
CAS#2203-97-6 (hemisuccinate anhydrous)

Theoretical Analysis

MedKoo Cat#: 571289

Name: Hydrocortisone hemisuccinate anhydrous

CAS#: 2203-97-6 (hemisuccinate anhydrous)

Chemical Formula: C25H34O8

Exact Mass: 462.2254

Molecular Weight: 462.54

Elemental Analysis: C, 64.92; H, 7.41; O, 27.67

Price and Availability

Size Price Availability Quantity
1g USD 385.00 2 Weeks
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Related CAS #
72590-77-3 (probutate) 57524-89-7 (valerate) 508-99-6 (cypionate) 125-04-2 (sodium succinate) 2203-97-6 (hemisuccinate anhydrous) 13609-67-1 (butyrate) 50-03-3 (Acetate) 74050-20-7 (aceponate) 50-23-7 (free base)
Synonym
Hydrocortisone hemisuccinate anhydrous; Cortisol succinate; Oralsome; Aftosome; Saxizon
IUPAC/Chemical Name
4-(2-((8S,9R,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoic acid
InChi Key
VWQWXZAWFPZJDA-WRCNZEDTSA-N
InChi Code
InChI=1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22-,23-,24-,25-/m0/s1
SMILES Code
C[C@]12C[C@H](O)[C@@H]([C@]3(C)C(CC4)=CC(CC3)=O)[C@@H]4[C@@H]1CC[C@]2(O)C(COC(CCC(O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 462.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hart KA, Dirikolu L, Ferguson DC, Norton NA, Barton MH. Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals. Am J Vet Res. 2012 Jan;73(1):68-75. doi: 10.2460/ajvr.73.1.68. Erratum in: Am J Vet Res. 2012 Mar;73(3):408. PubMed PMID: 22204290. 2: Lawrence CE, Wright JM, Knight CG. Cortisol succinate is slowly hydrolysed in organ cultures of porcine articular tissues and is not equivalent to cortisol. Cell Biochem Funct. 1986 Oct;4(4):277-81. PubMed PMID: 3791569. 3: Baud O, Maury L, Lebail F, Ramful D, El Moussawi F, Nicaise C, Zupan-Simunek V, Coursol A, Beuchée A, Bolot P, Andrini P, Mohamed D, Alberti C; PREMILOC trial study group. Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial. Lancet. 2016 Apr 30;387(10030):1827-36. doi: 10.1016/S0140-6736(16)00202-6. Epub 2016 Feb 23. PubMed PMID: 26916176. 4: Semark AJ, Venkatesh K, McWhinney BC, Pretorius C, Roberts JA, Cohen J, Venkatesh B. The compatibility of a low concentration of hydrocortisone sodium succinate with selected drugs during a simulated Y-site administration. Crit Care Resusc. 2013 Mar;15(1):63-6. PubMed PMID: 23432505. 5: Zeugswetter FK, Neffe F, Schwendenwein I, Tichy A, Möstl E. Configuration of antibodies for assay of urinary cortisol in dogs influences analytic specificity. Domest Anim Endocrinol. 2013 Aug;45(2):98-104. doi: 10.1016/j.domaniend.2013.06.003. Epub 2013 Jun 26. PubMed PMID: 23849086. 6: Li H, Hui F, Jianmin X. Effects of hydrocortisone sodium succinate on voltage-gated sodium current in trigeminal ganglion neurons of rat. Neurol Res. 2011 Apr;33(3):295-9. doi: 10.1179/016164110X12714125204515. PubMed PMID: 21513649. 7: Li C, Xu J, Yuan Y, Zheng L, Teng L, Li Y, Zhu H, Guo S, Yu X. [Effect of hydrocortisone sodium succinate on serum tumor necrosis factor-α and interleukin-10 in septic shock]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Jul;26(7):513-5. doi: 10.3760/cma. j. issn.2095-4352. 2014. 07.014. Chinese. PubMed PMID: 25027432. 8: Church DB, Lamb WA, Emslie DR. Plasma cortisol concentrations in normal dogs given hydrocortisone sodium succinate. Aust Vet J. 1999 May;77(5):316-7. PubMed PMID: 10376103. 9: Nucera E, Lombardo C, Aruanno A, Colagiovanni A, Buonomo A, de Pasquale T, Pecora V, Sabato V, Rizzi A, Pascolini L, Ricci AG, Schiavino D. 'Empty sella syndrome': a case of a patient with sodium succinate hydrocortisone allergy. Eur J Endocrinol. 2011 Jan;164(1):139-40. doi: 10.1530/EJE-10-0863. Epub 2010 Oct 20. PubMed PMID: 20961968. 10: Calogiuri GF, Nettis E, Di Leo E, Muratore L, Ferrannini A, Vacca A. Long-term selective IgE-mediated hypersensitivity to hydrocortisone sodium succinate. Allergol Immunopathol (Madr). 2013 May-Jun;41(3):206-8. doi: 10.1016/j.aller.2012.02.003. Epub 2012 Sep 19. PubMed PMID: 22999788. 11: Amaya-Mejía AS, Galindo-Pacheco LV, O'Farrill-Romanillos PM, Rodríguez-Mireles KA, Campos-Romero FH, del Rivero-Hernández L. [Utility of challenge test in immediate hypersensitivity to hydrocortisone sodium succinate]. Rev Alerg Mex. 2014 Jan-Mar;61(1):32-7. Review. Spanish. PubMed PMID: 24913000. 12: Saltzman W, Abbott DH. Effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (Callithrix jacchus). Psychoneuroendocrinology. 2009 Sep;34(8):1222-34. doi: 10.1016/j.psyneuen.2009.03.012. Epub 2009 Apr 11. PubMed PMID: 19362777; PubMed Central PMCID: PMC2716431. 13: Nuyt AM, Thébaud B. Not another steroid trial: early low-dose hydrocortisone in preterm infants. Lancet. 2016 Apr 30;387(10030):1793-4. doi: 10.1016/S0140-6736(16)00503-1. Epub 2016 Feb 23. PubMed PMID: 26916175. 14: Yeager MP, Rassias AJ, Pioli PA, Beach ML, Wardwell K, Collins JE, Lee HK, Guyre PM. Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin. Crit Care Med. 2009 Oct;37(10):2727-32. PubMed PMID: 19885996; PubMed Central PMCID: PMC2819133. 15: Wolf OT, Convit A, McHugh PF, Kandil E, Thorn EL, De Santi S, McEwen BS, de Leon MJ. Cortisol differentially affects memory in young and elderly men. Behav Neurosci. 2001 Oct;115(5):1002-11. PubMed PMID: 11584913. 16: Posener JA, DeBattista C, Williams GH, Schatzberg AF. Cortisol feedback during the HPA quiescent period in patients with major depression. Am J Psychiatry. 2001 Dec;158(12):2083-5. PubMed PMID: 11729034. 17: Durant S, Duval D, Homo-Delarche F. Effect of cortisol on the plasma and lymphoid tissue distributions of tritiated glucocorticoids in C57BL/6 mice. J Endocrinol. 1988 Jun;117(3):373-8. PubMed PMID: 3392494. 18: Jhunjhunwala VP, Bhalla HL. Compatibility of mephentermine sulfate with hydrocortisone sodium succinate or aminophylline in 5% dextrose injection. Am J Hosp Pharm. 1981 Dec;38(12):1922-4. PubMed PMID: 7325174. 19: You YC, Dong LY, Dong K, Xu W, Yan Y, Zhang L, Wang K, Xing FJ. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. doi: 10.1016/j.carbpol.2015.03.075. Epub 2015 Apr 27. PubMed PMID: 26076623. 20: Hu ZL, Liu H, Hu Y, Zhang DY, Sun ZQ, Jin MW. [Effects of hydrocortisone sodium succinate on sodium current in human and guinea pig cardiac myocytes]. Yao Xue Xue Bao. 2004 Apr;39(4):250-3. Chinese. PubMed PMID: 15303651.