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MedKoo Cat#: 461240 | Name: Hydrocortisone aceponate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydrocortisone aceponate is a corticosteroid that is used in form of creams for the treatment of various dermatoses.

Chemical Structure

Hydrocortisone aceponate
Hydrocortisone aceponate
CAS#74050-20-7 (aceponate)

Theoretical Analysis

MedKoo Cat#: 461240

Name: Hydrocortisone aceponate

CAS#: 74050-20-7 (aceponate)

Chemical Formula: C26H36O7

Exact Mass: 460.2461

Molecular Weight: 460.56

Elemental Analysis: C, 67.80; H, 7.88; O, 24.32

Price and Availability

Size Price Availability Quantity
10mg USD 285.00 2 Weeks
25mg USD 500.00 2 Weeks
50mg USD 750.00 2 Weeks
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Related CAS #
72590-77-3 (probutate) 57524-89-7 (valerate) 508-99-6 (cypionate) 125-04-2 (sodium succinate) 2203-97-6 (hemisuccinate anhydrous) 13609-67-1 (butyrate) 50-03-3 (Acetate) 74050-20-7 (aceponate) 50-23-7 (free base)
Synonym
Hydrocortisone aceponate; Efficort; Suniderma;
IUPAC/Chemical Name
(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate
InChi Key
MFBMYAOAMQLLPK-FZNHGJLXSA-N
InChi Code
InChI=1S/C26H36O7/c1-5-22(31)33-26(21(30)14-32-15(2)27)11-9-19-18-7-6-16-12-17(28)8-10-24(16,3)23(18)20(29)13-25(19,26)4/h12,18-20,23,29H,5-11,13-14H2,1-4H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1
SMILES Code
C[C@@]12[C@](C(COC(C)=O)=O)(OC(CC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 460.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nuttall TJ, McEwan NA, Bensignor E, Cornegliani L, Löwenstein C, Rème CA. Comparable efficacy of a topical 0.0584% hydrocortisone aceponate spray and oral ciclosporin in treating canine atopic dermatitis. Vet Dermatol. 2012 Feb;23(1):4-10, e1-2. doi: 10.1111/j.1365-3164.2011.00992.x. Epub 2011 Jul 1. PubMed PMID: 21718368. 2: Schmidt V, Buckley LM, McEwan NA, Rème CA, Nuttall TJ. Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: an open label pilot study. Vet Dermatol. 2012 Feb;23(1):11-6, e3-4. doi: 10.1111/j.1365-3164.2011.00993.x. Epub 2011 Jul 1. PubMed PMID: 21718369. 3: Nam EH, Park SH, Jung JY, Han SH, Youn HY, Chae JS, Hwang CY. Evaluation of the effect of a 0.0584% hydrocortisone aceponate spray on clinical signs and skin barrier function in dogs with atopic dermatitis. J Vet Sci. 2012 Jun;13(2):187-91. PubMed PMID: 22705741; PubMed Central PMCID: PMC3386344. 4: Wohlrab J, Beck GM, Neubert RH, Sischka U, Kreft B. Hydrocortisone aceponate activity and benefit/risk ratio in relation to reference topical glucocorticoids. Skin Pharmacol Physiol. 2010;23(4):177-82. doi: 10.1159/000288164. Epub 2010 Feb 25. PubMed PMID: 20185975. 5: Schmidt V, McEwan N, Nuttall T. Hydrocortisone aceponate. J Small Anim Pract. 2009 Jun;50(6):317. doi: 10.1111/j.1748-5827.2009.00776.x. PubMed PMID: 19527428. 6: Bonneau S, Skowronski V, Sanquer A, Maynard L, Eun HM. Therapeutic efficacy of topical hydrocortisone aceponate in experimental flea-allergy dermatitis in dogs. Aust Vet J. 2009 Jul;87(7):287-91. doi: 10.1111/j.1751-0813.2009.00447.x. PubMed PMID: 19573156. 7: Mukhopadhyay AK, Baghel V. A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients. Indian J Dermatol Venereol Leprol. 2010 Sep-Oct;76(5):591. doi: 10.4103/0378-6323.69093. PubMed PMID: 20827017. 8: Schmidt V, McEwan N, Nuttall T. Hydrocortisone aceponate is a potent and safe glucocorticoid. Vet Dermatol. 2009 Jun;20(3):199. doi: 10.1111/j.1365-3164.2009.00777.x. PubMed PMID: 19490577. 9: Nuttall T, Mueller R, Bensignor E, Verde M, Noli C, Schmidt V, Rème C. Efficacy of a 0.0584% hydrocortisone aceponate spray in the management of canine atopic dermatitis: a randomised, double blind, placebo-controlled trial. Vet Dermatol. 2009 Jun;20(3):191-8. doi: 10.1111/j.1365-3164.2009.00756.x. Epub 2009 Apr 3. PubMed PMID: 19374721. 10: El Sayed F, Ammoury A, Launais F, Bazex J. Contact dermatitis to hydrocortisone aceponate in Efficort cream inducing widespread reaction. Contact Dermatitis. 2005 Oct;53(4):242-3. PubMed PMID: 16191032. 11: Görmar FE, Bernd A, Holzmann H. [The effect of hydrocortisone aceponate on proliferation, total protein synthesis and collagen synthesis in human skin fibroblasts in vitro]. Arzneimittelforschung. 1990 Feb;40(2 Pt 1):192-6. German. PubMed PMID: 2334460. 12: Lourenço AM, Schmidt V, São Braz B, Nóbrega D, Nunes T, Duarte-Correia JH, Matias D, Maruhashi E, Rème CA, Nuttall T. Efficacy of proactive long-term maintenance therapy of canine atopic dermatitis with 0.0584% hydrocortisone aceponate spray: a double-blind placebo controlled pilot study. Vet Dermatol. 2016 Apr;27(2):88-92e25. doi: 10.1111/vde.12285. Epub 2016 Jan 25. PubMed PMID: 26804943. 13: Schäfer-Korting M, Korting HC, Kerscher MJ, Lenhard S. Prednicarbate activity and benefit/risk ratio in relation to other topical glucocorticoids. Clin Pharmacol Ther. 1993 Oct;54(4):448-56. PubMed PMID: 8222488. 14: Bizikova P, Linder KE, Paps J, Olivry T. Effect of a novel topical diester glucocorticoid spray on immediate- and late-phase cutaneous allergic reactions in Maltese-beagle atopic dogs: a placebo-controlled study. Vet Dermatol. 2010 Feb;21(1):70-9. doi: 10.1111/j.1365-3164.2009.00782.x. PubMed PMID: 20187913. 15: Kerscher MJ, Korting HC. Topical glucocorticoids of the non-fluorinated double-ester type. Lack of atrophogenicity in normal skin as assessed by high-frequency ultrasound. Acta Derm Venereol. 1992;72(3):214-6. PubMed PMID: 1357864. 16: Uri M, Buckley LM, Marriage L, McEwan N, Schmidt VM. A pilot study comparing in vitro efficacy of topical preparations against veterinary pathogens. Vet Dermatol. 2016 Jun;27(3):152-e39. doi: 10.1111/vde.12306. Epub 2016 Apr 24. PubMed PMID: 27109449. 17: Perego R, Proverbio D, Zuccaro A, Spada E. Low-level laser therapy: Case-control study in dogs with sterile pyogranulomatous pododermatitis. Vet World. 2016 Aug;9(8):882-7. doi: 10.14202/vetworld.2016.882-887. Epub 2016 Aug 22. PubMed PMID: 27651678; PubMed Central PMCID: PMC5021839. 18: Fujimura M, Ishimaru H. Influence of a Diester Glucocorticoid Spray on the Cortisol Level and the CCR4(+) CD4(+) Lymphocytes in Dogs with Atopic Dermatitis: Open Study. J Vet Med. 2014;2014:492735. doi: 10.1155/2014/492735. Epub 2014 Sep 21. Erratum in: J Vet Med. 2016;2016:6510347. PubMed PMID: 26464935; PubMed Central PMCID: PMC4590839. 19: Korting HC. Topical glucocorticoids and thinning of normal skin as to be assessed by ultrasound. Curr Probl Dermatol. 1993;21:114-21. PubMed PMID: 8299364. 20: Niedner R. [Risk of atrophy induced by recent topical glucocorticoids]. Hautarzt. 1995 Nov;46(11):812. German. PubMed PMID: 8641891.