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MedKoo Cat#: 573258 | Name: Hydrocortisone sodium succinate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydrocortisone sodium succinate is a glucocorticoid which is used to alleviate allergic reactions, particularly those of the skin and gums.

Chemical Structure

Hydrocortisone sodium succinate
Hydrocortisone sodium succinate
CAS#125-04-2 (sodium succinate)

Theoretical Analysis

MedKoo Cat#: 573258

Name: Hydrocortisone sodium succinate

CAS#: 125-04-2 (sodium succinate)

Chemical Formula: C25H33NaO8

Exact Mass:

Molecular Weight: 484.52

Elemental Analysis: C, 61.97; H, 6.87; Na, 4.74; O, 26.42

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
500mg USD 550.00 2 Weeks
1g USD 750.00 2 Weeks
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Related CAS #
72590-77-3 (probutate) 57524-89-7 (valerate) 508-99-6 (cypionate) 125-04-2 (sodium succinate) 2203-97-6 (hemisuccinate anhydrous) 13609-67-1 (butyrate) 50-03-3 (Acetate) 74050-20-7 (aceponate) 50-23-7 (free base)
Synonym
A-hydroCort, Arcocort, Buccalsone, Corlan, Cortop, Emi-Corlin, Hydrocort, Hydrocortisone sodium succinate, Idrocortisone B. I. L., Intracort, Lycortin-S, Nordicort, Nositrol, Oralsone, Rapicort, Solu-Cortef
IUPAC/Chemical Name
sodium 4-(2-((8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoate
InChi Key
HHZQLQREDATOBM-CODXZCKSSA-M
InChi Code
InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
SMILES Code
[H][C@@]12[C@@]([H])(CCC3=CC(CC[C@@]32C)=O)[C@@]([H])([C@@]4(C[C@@H]1O)C)CC[C@@]4(C(COC(CCC([O-])=O)=O)=O)O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM.
In vitro activity:
Steroidal anti-inflammatory drugs (SAIDs) exhibited significant inhibitory effects at 100 microM on the IL-6 bioactivity, and their inhibitory potencies were in the order of budesonide (IC50=2.2 microM)>hydrocortisone 21-hemisuccinate (6.7 microM), prednisolone (7.5 microM), betamethasone (10.9 microM)>dexamethasone (18.9 microM) and triamcinolone acetonide (24.1 microM). Reference: Biol Pharm Bull. 2001 Jun;24(6):701-3. https://pubmed.ncbi.nlm.nih.gov/11411563/
In vivo activity:
Two-way ANOVA revealed significantly increased plasma testosterone levels at 120 min (P ≤ 0.0037), 180 min (P ≤ 0.0016), and 240 min (P ≤ 0.0001) intervals in hydrocortisone treated monkeys. These results are suggesting an acute stimulation of plasma testosterone by RF9 compared to vehicle. Mean plasma testosterone after RF9 and vehicle administration in the hydrocortisone treated monkeys are shown in Figure 2. Reference: Front Physiol. 2021 Feb 25;12:630796. https://pubmed.ncbi.nlm.nih.gov/33716777/
Solvent mg/mL mM
Solubility
DMF 30.0 61.92
DMSO 125.7 259.36
Ethanol 22.0 45.41
PBS (pH 7.2) 10.0 20.64
Water 97.0 200.20
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 484.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kang BS, Chung EY, Yun YP, Lee MK, Lee YR, Lee KS, Min KR, Kim Y. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. doi: 10.1248/bpb.24.701. PMID: 11411563. 2. Klempner MS, Gallin JI. Inhibition of neutrophil Fc receptor function by cotricosteroids. Clin Exp Immunol. 1978 Oct;34(1):137-42. PMID: 750117; PMCID: PMC1537461. 3. Ullah R, Naz R, Batool A, Wazir M, Rahman TU, Nabi G, Wahab F, Fu J, Shahab M. RF9 Rescues Cortisol-Induced Repression of Testosterone Levels in Adult Male Macaques. Front Physiol. 2021 Feb 25;12:630796. doi: 10.3389/fphys.2021.630796. PMID: 33716777; PMCID: PMC7946976. 4. Liu XY, Shi JH, DU WH, Fan YP, Hu XL, Zhang CC, Xu HB, Miao YJ, Zhou HY, Xiang P, Chen FL. Glucocorticoids decrease body weight and food intake and inhibit appetite regulatory peptide expression in the hypothalamus of rats. Exp Ther Med. 2011 Sep;2(5):977-984. doi: 10.3892/etm.2011.292. Epub 2011 Jun 21. PMID: 22977608; PMCID: PMC3440759.
In vitro protocol:
1. Kang BS, Chung EY, Yun YP, Lee MK, Lee YR, Lee KS, Min KR, Kim Y. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. doi: 10.1248/bpb.24.701. PMID: 11411563. 2. Klempner MS, Gallin JI. Inhibition of neutrophil Fc receptor function by cotricosteroids. Clin Exp Immunol. 1978 Oct;34(1):137-42. PMID: 750117; PMCID: PMC1537461.
In vivo protocol:
1. Ullah R, Naz R, Batool A, Wazir M, Rahman TU, Nabi G, Wahab F, Fu J, Shahab M. RF9 Rescues Cortisol-Induced Repression of Testosterone Levels in Adult Male Macaques. Front Physiol. 2021 Feb 25;12:630796. doi: 10.3389/fphys.2021.630796. PMID: 33716777; PMCID: PMC7946976. 2. Liu XY, Shi JH, DU WH, Fan YP, Hu XL, Zhang CC, Xu HB, Miao YJ, Zhou HY, Xiang P, Chen FL. Glucocorticoids decrease body weight and food intake and inhibit appetite regulatory peptide expression in the hypothalamus of rats. Exp Ther Med. 2011 Sep;2(5):977-984. doi: 10.3892/etm.2011.292. Epub 2011 Jun 21. PMID: 22977608; PMCID: PMC3440759.
1: Davoudi Z, Rabiee M, Houshmand B, Eslahi N, Khoshroo K, Rasoulianboroujeni M, Tahriri M, Tayebi L. Development of chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis. Drug Dev Ind Pharm. 2018 Jan;44(1):40-55. doi: 10.1080/03639045.2017.1371738. Epub 2017 Sep 13. PubMed PMID: 28832260. 2: Dong K, Zhang H, Yan Y, Sun J, Dong Y, Wang K, Zhang L, Shi X, Xing J. Improvement of side-effects and treatment on the experimental colitis in mice of a resin microcapsule-loading hydrocortisone sodium succinate. Drug Dev Ind Pharm. 2017 Mar;43(3):448-457. doi: 10.1080/03639045.2016.1258410. Epub 2016 Nov 21. PubMed PMID: 27819157. 3: Calogiuri GF, Nettis E, Di Leo E, Muratore L, Ferrannini A, Vacca A. Long-term selective IgE-mediated hypersensitivity to hydrocortisone sodium succinate. Allergol Immunopathol (Madr). 2013 May-Jun;41(3):206-8. doi: 10.1016/j.aller.2012.02.003. Epub 2012 Sep 19. PubMed PMID: 22999788.