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MedKoo Cat#: 413292 | Name: Hydrocortisone valerate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydrocortisone valerate is a glucocorticoid used in treatment of atopic dermatitis.

Chemical Structure

Hydrocortisone valerate
Hydrocortisone valerate
CAS#57524-89-7 (valerate)

Theoretical Analysis

MedKoo Cat#: 413292

Name: Hydrocortisone valerate

CAS#: 57524-89-7 (valerate)

Chemical Formula: C26H38O6

Exact Mass: 446.2668

Molecular Weight: 446.58

Elemental Analysis: C, 69.93; H, 8.58; O, 21.50

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Related CAS #
72590-77-3 (probutate) 57524-89-7 (valerate) 508-99-6 (cypionate) 125-04-2 (sodium succinate) 2203-97-6 (hemisuccinate anhydrous) 13609-67-1 (butyrate) 50-03-3 (Acetate) 74050-20-7 (aceponate) 50-23-7 (free base)
Synonym
Hydrocortisone valerate; Westcort; Cortisol 17-valerate
IUPAC/Chemical Name
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate
InChi Key
FZCHYNWYXKICIO-FZNHGJLXSA-N
InChi Code
InChI=1S/C26H38O6/c1-4-5-6-22(31)32-26(21(30)15-27)12-10-19-18-8-7-16-13-17(28)9-11-24(16,2)23(18)20(29)14-25(19,26)3/h13,18-20,23,27,29H,4-12,14-15H2,1-3H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1
SMILES Code
C[C@@]12[C@](C(CO)=O)(OC(CCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 446.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sefton J, Loder JS, Kyriakopoulos AA. Clinical evaluation of hydrocortisone valerate 0.2% ointment. Clin Ther. 1984;6(3):282-93. PMID: 6373007. 2: Roth HL, Brown EP. Hydrocortisone valerate. Double-blind comparison with two other topical steroids. Cutis. 1978 May;21(5):695-8. PMID: 348406. 3: TOPICAL hydrocortisone. Br Med J. 1955 Feb 26;1(4912):530-1. PMID: 13230548; PMCID: PMC2061204. 4: Sefton J, Kyriakopoulos AA. Comparative efficacy of hydrocortisone valerate 0.2 percent ointment in the treatment of atopic dermatitis. Cutis. 1983 Jul;32(1):89-91, 94. PMID: 6349943. 5: Lebwohl M. A comparison of once-daily application of mometasone furoate 0.1% cream compared with twice-daily hydrocortisone valerate 0.2% cream in pediatric atopic dermatitis patients who failed to respond to hydrocortisone: mometasone furoate study group. Int J Dermatol. 1999 Aug;38(8):604-6. doi: 10.1046/j.1365-4362.1999.00759.x. PMID: 10487451. 6: Koch EM. Contact allergic reaction to valerate esters of betamethasone and hydrocortisone. Contact Dermatitis. 1985 Jan;12(1):58. doi: 10.1111/j.1600-0536.1985.tb01048.x. PMID: 3979047. 7: BALLABIO CB, SALA G, AMIRA A. Topical hydrocortisone in pleuropericardial exudations. Dis Chest. 1955 Feb;27(2):190-5. doi: 10.1378/chest.27.2.190. PMID: 13231750. 8: Prakash A, Benfield P. Topical mometasone. A review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders. Drugs. 1998 Jan;55(1):145-63. doi: 10.2165/00003495-199855010-00009. PMID: 9463794. 9: GOLTZ RW. Topical hydrocortisone in the treatment of skin diseases. Minn Med. 1955 Jun;38(6):404-7. PMID: 14393933. 10: WAY SC, ANDREWS GC, DOMONKOS AN. Topical hydrocortisone therapy in acne rosacea and acne vulgaris. N Y State J Med. 1957 Nov 1;57(21):3463-5. PMID: 13477455.