MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 598204 | Name: Hydrocortisone butyrate
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydrocortisone butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.

Chemical Structure

Hydrocortisone butyrate
Hydrocortisone butyrate
CAS#13609-67-1 (butyrate)

Theoretical Analysis

MedKoo Cat#: 598204

Name: Hydrocortisone butyrate

CAS#: 13609-67-1 (butyrate)

Chemical Formula: C25H36O6

Exact Mass: 432.2512

Molecular Weight: 432.55

Elemental Analysis: C, 69.42; H, 8.39; O, 22.19

Price and Availability

Size Price Availability Quantity
1g USD 385.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
72590-77-3 (probutate) 57524-89-7 (valerate) 508-99-6 (cypionate) 125-04-2 (sodium succinate) 2203-97-6 (hemisuccinate anhydrous) 13609-67-1 (butyrate) 50-03-3 (Acetate) 74050-20-7 (aceponate) 50-23-7 (free base)
Synonym
Hydrocortisone butyrate; H.17B; Locoid; Locoid lipocream; Alfason; Hydrocortisone 17-butyrate;
IUPAC/Chemical Name
(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate
InChi Key
BMCQMVFGOVHVNG-TUFAYURCSA-N
InChi Code
InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1
SMILES Code
C[C@@]12[C@](C(CO)=O)(OC(CCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 432.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang X, Patel S, Sheng Y, Pal D, Mitra AK. Statistical design for formulation optimization of hydrocortisone butyrate-loaded PLGA nanoparticles. AAPS PharmSciTech. 2014 Jun;15(3):569-87. doi: 10.1208/s12249-014-0072-4. Epub 2014 Feb 7. PubMed PMID: 24504495; PubMed Central PMCID: PMC4037477. 2: Savchenko L, Vrakin V, Georgiyants V. Development of the hydrocortisone butyrate qualitative determination method. Ceska Slov Farm. Fall 2014;63(6):275. PubMed PMID: 26837875. 3: Yang X, Trinh HM, Agrahari V, Sheng Y, Pal D, Mitra AK. Nanoparticle-Based Topical Ophthalmic Gel Formulation for Sustained Release of Hydrocortisone Butyrate. AAPS PharmSciTech. 2016 Apr;17(2):294-306. doi: 10.1208/s12249-015-0354-5. Epub 2015 Jun 18. PubMed PMID: 26085051; PubMed Central PMCID: PMC4984892. 4: Haapasaari KM, Risteli J, Koivukangas V, Oikarinen A. Comparison of the effect of hydrocortisone, hydrocortisone-17-butyrate and betamethasone on collagen synthesis in human skin in vivo. Acta Derm Venereol. 1995 Jul;75(4):269-71. PubMed PMID: 8578945. 5: Korting HC, Maslen K, Gross G, Willers C. [Comparison of activity of different topical corticosteroid creams and ointments using a vasoconstriction assay: superiority of hydrocortisone butyrate over hydrocortisone]. J Dtsch Dermatol Ges. 2005 May;3(5):348-53. German. PubMed PMID: 16372801. 6: Yip YW, Li Wan Po A, Irwin WJ. Kinetics of decomposition and formulation of hydrocortisone butyrate in semiaqueous and gel systems. J Pharm Sci. 1983 Jul;72(7):776-81. PubMed PMID: 6886985. 7: D'Erme AM, Gola M. Allergic contact dermatitis induced by topical hydrocortisone-17-butyrate mimicking papular rosacea. Dermatitis. 2012 Mar-Apr;23(2):95-6. doi: 10.1097/DER.0b013e31824a609f. PubMed PMID: 22653130. 8: Reitamo S, Rustin M, Ruzicka T, Cambazard F, Kalimo K, Friedmann PS, Schoepf E, Lahfa M, Diepgen TL, Judodihardjo H, Wollenberg A, Berth-Jones J, Bieber T; European Tacrolimus Ointment Study Group. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis. J Allergy Clin Immunol. 2002 Mar;109(3):547-55. PubMed PMID: 11898005. 9: Matheson R, Kempers S, Breneman D, Draelos Z, Johnson CE, Loss R, Hogan DJ, Schoenfeld R, Checketts S, Kircik L, Fivenson D, Hebert AA, Williams J, Hamlin R, Groisser D, Piacquadio D. Hydrocortisone butyrate 0.1% lotion in the treatment of atopic dermatitis in pediatric subjects. J Drugs Dermatol. 2008 Mar;7(3):266-71. PubMed PMID: 18380208. 10: Veien NK, Hattel T, Justesen O, Nørholm A, Verjans HL. Hydrocortisone 17-butyrate (Locoid) 0.1% cream versus hydrocortisone (Uniderm) 1% cream in the treatment of children suffering from atopic dermatitis. J Int Med Res. 1984;12(5):310-3. PubMed PMID: 6389217. 11: Fowler JF Jr, Fransway AF, Jackson JM, Rohowsky N. Hydrocortisone butyrate 0.1% cream in the treatment of chronic dermatitis. Cutis. 2005 Feb;75(2):125-31. PubMed PMID: 15773535. 12: Lassus A. Clobetasone butyrate and hydrocortisone butyrate in the treatment of eczema: a double-blind comparison. Curr Med Res Opin. 1979;6(3):165-7. PubMed PMID: 391489. 13: Lassus A. Clinical comparison of alclometasone dipropionate cream 0.05% with hydrocortisone butyrate cream 0.1% in the treatment of atopic dermatitis in children. J Int Med Res. 1983;11(5):315-9. PubMed PMID: 6357892. 14: Lauerma AI. Screening for corticosteroid contact sensitivity. Comparison of tixocortol pivalate, hydrocortisone-17-butyrate and hydrocortisone. Contact Dermatitis. 1991 Feb;24(2):123-30. PubMed PMID: 1828209. 15: Ruth M, Ekström T, Aberg B, Edström S. A clinical comparison of hydrocortisone butyrate with oxytetracycline/hydrocortisone acetate-polymyxin B in the local treatment of acute external otitis. Eur Arch Otorhinolaryngol. 1990;247(2):77-80. PubMed PMID: 2156538. 16: Rajka G, Verjans HL. Hydrocortisone 17-butyrate (Locoid) 0.1% fatty cream versus desonide (Apolar) 0.1% ointment in the treatment of patients suffering from atopic dermatitis. J Int Med Res. 1986;14(2):85-90. PubMed PMID: 3516754. 17: Abramovits W, Oquendo M. Hydrocortisone butyrate 0.1% cream (proprietary lipid rich cream vehicle) does not significantly suppress hypothalamic-pituitary-adrenal axis and is effective in pediatric patients 3 months and older with extensive atopic dermatitis. Skinmed. 2010 May-Jun;8(3):150-4. PubMed PMID: 21137620. 18: Eichenfield L, Ellis CN, Fivenson D, Hebert AA, Dromgoole S, Piacquadio D. Evaluation of adrenal suppression of a lipid enhanced, topical emollient cream formulation of hydrocortisone butyrate 0.1% in treating children with atopic dermatitis. Pediatr Dermatol. 2007 Jan-Feb;24(1):81-4. PubMed PMID: 17300659. 19: Marston S. Contact dermatitis from cetostearyl alcohol in hydrocortisone butyrate lipocream, and from lanolin. Contact Dermatitis. 1991 May;24(5):372. PubMed PMID: 1832620. 20: Kejda J. [Hydrocortisone 17-butyrate and hydrocortisone acetate. Comparison in chronic eczema]. Dermatol Monatsschr. 1984;170(7):448-52. German. PubMed PMID: 6381150.