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MedKoo Cat#: 596510 | Name: Tinofedrine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tinofedrine HCl is a vasodilator.

Chemical Structure

Tinofedrine HCl
CAS#50776-39-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 596510

Name: Tinofedrine HCl

CAS#: 50776-39-1 (HCl)

Chemical Formula: C20H22ClNOS2

Exact Mass:

Molecular Weight: 391.97

Elemental Analysis: C, 61.28; H, 5.66; Cl, 9.04; N, 3.57; O, 4.08; S, 16.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
36702-83-7 (free base) 50776-39-1 (HCl)
Synonym
Tinofedrine hydrochloride; Novocebrin hydrochloride;
IUPAC/Chemical Name
(1R,2S)-2-((3,3-di(thiophen-3-yl)allyl)amino)-1-phenylpropan-1-ol hydrochloride
InChi Key
BRPBPTNOXZNOML-QNNMEKCMSA-N
InChi Code
InChI=1S/C20H21NOS2.ClH/c1-15(20(22)16-5-3-2-4-6-16)21-10-7-19(17-8-11-23-13-17)18-9-12-24-14-18;/h2-9,11-15,20-22H,10H2,1H3;1H/t15-,20-;/m0./s1
SMILES Code
C[C@H](NC/C=C(c1cscc1)/c2cscc2)[C@H](O)c3ccccc3.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 391.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Engel J, von Schlichtegroll A, Sheldrick WS. Synthesis and absolute configuration of a tinofedrine-oxazolidine derivative. Arzneimittelforschung. 1982;32(5):475-7. PubMed PMID: 7201821. 2: Ott E, Lechner H. [The effect of tiofedrine on brain perfusion in patients with cerebrovascular insufficiency]. Z Gesamte Inn Med. 1981 Feb 15;36(4):124-6. German. PubMed PMID: 7222859. 3: Stroman F, Thiemer K. [Investigations on the general effects of tinofedrine on heart and blood circulation (author's transl)]. Arzneimittelforschung. 1981;31(11):1892-902. German. PubMed PMID: 7198471. 4: Kleemann A, Heese J, Engel J. [Synthesis of germinal 3,3-dithienyl compounds (author's transl)]. Arzneimittelforschung. 1981;31(8):1178-83. German. PubMed PMID: 7197525. 5: Thjemer K, Obermeier K. [Effect of tinofedrine on oxygen, glucose and lactate metabolism in dogs and rats]. Arzneimittelforschung. 1981;31(4):693-700. German. PubMed PMID: 7195717. 6: Lehmann R, Denes R, Nienhaus R, Steinbach T, Lusztig G, Sanatger RM. Alteration of chromatin in early experimental arteriosclerosis. Artery. 1980;8(3):288-93. PubMed PMID: 7213038. 7: Thiele K, Posselt K, Heese J, Engel J. [Spectroscopic characterisation of tinofedrine (author's transl)]. Arzneimittelforschung. 1980;30(7):1057-9. German. PubMed PMID: 7191286. 8: Saus A, Posselt K. [Synthesis of radioactively labelled tinofedrine (author's transl)]. Arzneimittelforschung. 1980;30(6):917-8. German. PubMed PMID: 7191263. 9: Thiele K, Posselt K, Offermanns H, Thiemer K. [New cerebrally active basic dithienyl compounds (author's tranls)]. Arzneimittelforschung. 1980;30(5):747-51. German. PubMed PMID: 7190413. 10: Lechner H, Ott E. [The influence of tinofedrine on fibrinogen and platelet aggregation in patients with recent cerebral infarction (author's transl)]. Klin Wochenschr. 1978 Nov 15;56(22):1137-8. German. PubMed PMID: 713434. 11: Merory J, Du Boulay GH, Marshall J, Morris J, Russell RW, Symon L, Thomas DJ. Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia. J Neurol Neurosurg Psychiatry. 1978 Oct;41(10):900-2. PubMed PMID: 731238; PubMed Central PMCID: PMC493190. 12: Thiele K, Posselt K, Offermanns H. [On the synthesis of the cerebrally active compound tinofedrine (author's transl)]. Arzneimittelforschung. 1978;28(11):2047-8. German. PubMed PMID: 582902. 13: Obermeier K, Niebch G, Thiemer K, Vergin H. [Studies on the pharmacokinetics and metabolism of tinofedrine]. Arzneimittelforschung. 1978;28(8):1360-7. German. PubMed PMID: 582402. 14: Obermeier K, Thiemer K, von Schlichtegroll A. [The influence of tinofedrine on cerebral energy metabolism in normotensive, hypotensive and hypoxemic rats after carotis ligation (author's transl)]. Arzneimittelforschung. 1978;28(8):1354-60. German. PubMed PMID: 582401. 15: Thiemer K, Stroman F, Szelenyi I, von Schlichtegroll A. [Pharmacological effect of tinofedrine on cerebral and peripheral hemodynamics in the dog (author's transl)]. Arzneimittelforschung. 1978;28(8):1343-54. German. PubMed PMID: 582400. 16: Jakovlev V, Thiemer K, Habersang S, Achterrath-Tuckermann U, von Schlichtegroll A, Sofia RD. [General pharmacological studies on tinofedrine (author's transl)]. Arzneimittelforschung. 1978;28(8):1335-43. German. PubMed PMID: 582399. 17: Spehr W. [The effect of tinofedrine on the EEG]. Arzneimittelforschung. 1978;28(8):1312-3. German. PubMed PMID: 582394.