Synonym
Tinofedrine Free Base; D8955; D-8955; D 8955
IUPAC/Chemical Name
Benzenemethanol, alpha-(1-((3,3-di-3-thienyl-2-propenyl)amino)ethyl)-
InChi Key
JQSHEDRVRBSFCZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21NOS2/c1-15(20(22)16-5-3-2-4-6-16)21-10-7-19(17-8-11-23-13-17)18-9-12-24-14-18/h2-9,11-15,20-22H,10H2,1H3
SMILES Code
OC(C(NC/C=C(C1=CSC=C1)/C2=CSC=C2)C)C3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
355.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Obermeier K, Niebch G, Thiemer K, Vergin H. Untersuchungen zu Pharmakokinetik und Metabolismus von Tinofedrin [Studies on the pharmacokinetics and metabolism of tinofedrine]. Arzneimittelforschung. 1978;28(8):1360-7. German. PMID: 582402.
2: Stroman F, Thiemer K. Untersuchungen zur allgemeinen Herz- und Kreislaufwirkung des Tinofedrin [Investigations on the general effects of tinofedrine on heart and blood circulation (author's transl)]. Arzneimittelforschung. 1981;31(11):1892-902. German. PMID: 7198471.
3: Thiele K, Posselt K, Heese J, Engel J. Spektroskopische Charakterisierung von Tinofedrin [Spectroscopic characterisation of tinofedrine (author's transl)]. Arzneimittelforschung. 1980;30(7):1057-9. German. PMID: 7191286.
4: Thiemer K, Stroman F, Szelenyi I, von Schlichtegroll A. Pharmakologische Wirkung von Tinofedrin auf die zerebrale und periphere Hämodynamik des Hundes [Pharmacological effect of tinofedrine on cerebral and peripheral hemodynamics in the dog (author's transl)]. Arzneimittelforschung. 1978;28(8):1343-54. German. PMID: 582400.
5: Spehr W. Zur Zeitgestalt des Elektroenzephalogramms unter Tinofedrin [The effect of tinofedrine on the EEG]. Arzneimittelforschung. 1978;28(8):1312-3. German. PMID: 582394.
6: Thjemer K, Obermeier K. Einflub von Tinofedrin auf den Sauerstoff-, Glukose- und Laktat-Stoffwechsel des Hundes und der Ratte [Effect of tinofedrine on oxygen, glucose and lactate metabolism in dogs and rats]. Arzneimittelforschung. 1981;31(4):693-700. German. PMID: 7195717.
7: Thiele K, Posselt K, Offermanns H. Zur Synthese der zerebroaktiven Substanz Tinofedrin [On the synthesis of the cerebrally active compound tinofedrine (author's transl)]. Arzneimittelforschung. 1978;28(11):2047-8. German. PMID: 582902.
8: Obermeier K, Thiemer K, von Schlichtegroll A. Einfluss von Tinofedrin auf den zerebralen Energiestoffwechsel von normotonen, hypotonen und hypoxämischen Ratten nach Carotis-Verschluss [The influence of tinofedrine on cerebral energy metabolism in normotensive, hypotensive and hypoxemic rats after carotis ligation (author's transl)]. Arzneimittelforschung. 1978;28(8):1354-60. German. PMID: 582401.
9: Lechner H, Ott E. Die Wirkung von Tinofedrin auf Fibrinogen und spontane Thrombozytenaggregation bei Patienten mit zerebrovaskulärer Insuffizienz [The influence of tinofedrine on fibrinogen and platelet aggregation in patients with recent cerebral infarction (author's transl)]. Klin Wochenschr. 1978 Nov 15;56(22):1137-8. German. doi: 10.1007/BF01477137. PMID: 713434.
10: Merory J, Du Boulay GH, Marshall J, Morris J, Russell RW, Symon L, Thomas DJ. Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi- infarct dementia. J Neurol Neurosurg Psychiatry. 1978 Oct;41(10):900-2. doi: 10.1136/jnnp.41.10.900. PMID: 731238; PMCID: PMC493190.
