Synonym
CGS 12066A; CGS12066A; CGS-12066A
IUPAC/Chemical Name
Pyrrolo(1,2-a)quinoxaline, 4-(4-methyl-1-piperazinyl)-7-(trifluoromethyl)-, ethanedioate (1:1)
InChi Key
RRTXUQKIVYYULV-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17F3N4.C2H2O4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16;3-1(4)2(5)6/h2-6,11H,7-10H2,1H3;(H,3,4)(H,5,6)
SMILES Code
FC(C1=CC2=C(N3C(C(N4CCN(C)CC4)=N2)=CC=C3)C=C1)(F)F.O=C(O)C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
424.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Jeong HS, Jang MJ, Park JS. Effects of CGS-12066A on medial vestibular nuclear neurons. Brain Res. 2005 Mar 15;1038(1):118-21. doi: 10.1016/j.brainres.2005.01.025. PMID: 15748881.
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8: Joppa MA, Rowe RK, Meisel RL. Effects of serotonin 1A or 1B receptor agonists on social aggression in male and female Syrian hamsters. Pharmacol Biochem Behav. 1997 Oct;58(2):349-53. doi: 10.1016/s0091-3057(97)00277-3. PMID: 9300591.
9: Middlemiss DN, Hutson PH. The 5-HT1B receptors. Ann N Y Acad Sci. 1990;600:132-47; discussion 347-48. doi: 10.1111/j.1749-6632.1990.tb16878.x. PMID: 2252306.
10: Lu CW, Lin TY, Huang SK, Wang SJ. 5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:122-130. doi: 10.1016/j.pnpbp.2018.05.019. Epub 2018 May 24. PMID: 29803926.
