Synonym
CGS 12066B; CGS12066B; CGS-12066B
IUPAC/Chemical Name
4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate
InChi Key
HTEVMLYDEWVIQE-SPIKMXEPSA-N
InChi Code
InChI=1S/C17H17F3N4.2C4H4O4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16;2*5-3(6)1-2-4(7)8/h2-6,11H,7-10H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
SMILES Code
CN1CCN(C(C2=CC=CN32)=NC4=C3C=CC(C(F)(F)F)=C4)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
566.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Neale, R.F., Fallon, S.L., Boyar, W.C., et al. Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-lB agonist. Eur. J. Pharmacol. 136(1), 1-9 (1987).
2: Unsworth, C.D., and Molinoff, P.B. Regulation of the 5-hydroxytryptamine1B receptor in opossum kidney cells after exposure to agonists. Mol. Pharmacol. 42(3), 464-470 (1992).
3: Joppa, M.A., Rowe, R.K., and Meisel, R.L. Effects of serotonin 1A or 1B receptor agonists on social aggression in male and female Syrian hamsters. Pharmacol. Biochem. Behav. 58(2), 349-353 (1997).
