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MedKoo Cat#: 581353 | Name: CL 277082

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CL 277082 is a boichemical.

Chemical Structure

CL 277082
CL 277082
CAS#96224-26-9

Theoretical Analysis

MedKoo Cat#: 581353

Name: CL 277082

CAS#: 96224-26-9

Chemical Formula: C26H36F2N2O

Exact Mass: 430.2796

Molecular Weight: 430.58

Elemental Analysis: C, 72.53; H, 8.43; F, 8.82; N, 6.51; O, 3.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CL 277082; Ddpmhu; CL277082; CL-277082;
IUPAC/Chemical Name
Urea, N'-(2,4-difluorophenyl)-N-((4-(2,2-dimethylpropyl)phenyl)methyl)-N-heptyl-
InChi Key
QKJLDOBXDUVGEE-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H36F2N2O/c1-5-6-7-8-9-16-30(25(31)29-24-15-14-22(27)17-23(24)28)19-21-12-10-20(11-13-21)18-26(2,3)4/h10-15,17H,5-9,16,18-19H2,1-4H3,(H,29,31)
SMILES Code
O=C(NC1=CC=C(F)C=C1F)N(CC2=CC=C(CC(C)(C)C)C=C2)CCCCCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 430.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pal S, Allister E, Thomson A, Mamo JC. Cholesterol esters regulate apoB48 secretion in CaCo2 cells. Atherosclerosis. 2002 Mar;161(1):55-63. PubMed PMID: 11882317. 2: Kusunoki J, Aragane K, Kitamine T, Yamaura T, Ohnishi H. [Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells]. Nihon Yakurigaku Zasshi. 1997 Dec;110(6):357-65. Japanese. PubMed PMID: 9503394. 3: Ellsworth JL, Starr JR. Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. Metabolism. 1998 Mar;47(3):325-32. PubMed PMID: 9500571. 4: Hawke RL, Chapman JM, Winegar DA, Salisbury JA, Welch RM, Brown A, Franzmann KW, Sigel C. Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity. J Lipid Res. 1997 Jun;38(6):1189-203. PubMed PMID: 9215547. 5: Martins IJ, Mortimer BC, Redgrave TG. Effect of the ACAT inhibitor CL 277,082 on apolipoprotein B48 transport in mesenteric lymph and on plasma clearance of chylomicrons and remnants. Arterioscler Thromb Vasc Biol. 1997 Jan;17(1):211-6. PubMed PMID: 9012658. 6: Graham A, Wood JL, Russell LJ. Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells. Biochim Biophys Acta. 1996 Jul 12;1302(1):46-54. PubMed PMID: 8695654. 7: Hassall DG, Graham A. Changes in free cholesterol content, measured by filipin fluorescence and flow cytometry, correlate with changes in cholesterol biosynthesis in THP-1 macrophages. Cytometry. 1995 Dec 1;21(4):352-62. PubMed PMID: 8608733. 8: Harte RA, Yeaman SJ, Jackson B, Suckling KE. Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors. Biochim Biophys Acta. 1995 Oct 5;1258(3):241-50. PubMed PMID: 7548193. 9: Fujiwara R, Shimada A, Tamai T, Nakai T, Miyabo S. Effects of insulin, insulin-like growth factor-I, and phorbol esters on neutral cholesteryl esterase activity in cultured rat vascular smooth muscle cells. J Lab Clin Med. 1995 Sep;126(3):240-9. PubMed PMID: 7665972. 10: Burrier RE, Deren S, McGregor DG, Hoos LM, Smith AA, Davis HR Jr. Demonstration of a direct effect on hepatic acyl CoA: cholesterol acyl transferase (ACAT) activity by an orally administered enzyme inhibitor in the hamster. Biochem Pharmacol. 1994 Apr 29;47(9):1545-51. PubMed PMID: 8185666. 11: Sliskovic DR, Krause BR, Picard JA, Anderson M, Bousley RF, Hamelehle KL, Homan R, Julian TN, Rashidbaigi ZA, Stanfield RL. Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity. J Med Chem. 1994 Mar 4;37(5):560-2. PubMed PMID: 8126693. 12: Krause BR, Black A, Bousley R, Essenburg A, Cornicelli J, Holmes A, Homan R, Kieft K, Sekerke C, Shaw-Hes MK, et al. Divergent pharmacologic activities of PD 132301-2 and CL 277,082, urea inhibitors of acyl-CoA:cholesterol acyltransferase. J Pharmacol Exp Ther. 1993 Nov;267(2):734-43. PubMed PMID: 8246149. 13: Trivedi BK, Holmes A, Stoeber TL, Blankley CJ, Roark WH, Picard JA, Shaw MK, Essenburg AD, Stanfield RL, Krause BR. Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents. J Med Chem. 1993 Oct 29;36(22):3300-7. PubMed PMID: 8230120. 14: Roach PD, Balasubramaniam S, Hirata F, Abbey M, Szanto A, Simons LA, Nestel PJ. The low-density lipoprotein receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat. Biochim Biophys Acta. 1993 Oct 13;1170(2):165-72. PubMed PMID: 8399341. 15: Maechler P, Wollheim CB, Bentzen CL, Niesor E. Importance of exogenous cholesterol in diabetic rats: effects of treatment with insulin or with an acyl-CoA:cholesterol acyltransferase inhibitor. Ann Nutr Metab. 1993;37(4):199-209. PubMed PMID: 8215237. 16: Maechler P, Wollheim CB, Bentzen CL, Niesor E. Role of the intestinal acyl-CoA:cholesterol acyltransferase activity in the hyperresponse of diabetic rats to dietary cholesterol. J Lipid Res. 1992 Oct;33(10):1475-84. PubMed PMID: 1431572. 17: Schnitzer-Polokoff R, Compton D, Boykow G, Davis H, Burrier R. Effects of acyl-CoA: cholesterol O-acyltransferase inhibition on cholesterol absorption and plasma lipoprotein composition in hamsters. Comp Biochem Physiol A Comp Physiol. 1991;99(4):665-70. PubMed PMID: 1679704. 18: Harris WS, Dujovne CA, von Bergmann K, Neal J, Akester J, Windsor SL, Greene D, Look Z. Effects of the ACAT inhibitor CL 277,082 on cholesterol metabolism in humans. Clin Pharmacol Ther. 1990 Aug;48(2):189-94. PubMed PMID: 2199133. 19: Balasubramaniam S, Simons LA, Chang S, Roach PD, Nestel PJ. On the mechanism by which an ACAT inhibitor (CL 277,082) influences plasma lipoproteins in the rat. Atherosclerosis. 1990 May;82(1-2):1-5. PubMed PMID: 2360913. 20: Largis EE, Wang CH, DeVries VG, Schaffer SA. CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989 May;30(5):681-90. PubMed PMID: 2760542.

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