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MedKoo Cat#: 317896 | Name: Flurbiprofen
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.

Chemical Structure

Flurbiprofen
Flurbiprofen
CAS#5104-49-4 (free acid)

Theoretical Analysis

MedKoo Cat#: 317896

Name: Flurbiprofen

CAS#: 5104-49-4 (free acid)

Chemical Formula: C15H13FO2

Exact Mass: 244.0900

Molecular Weight: 244.26

Elemental Analysis: C, 73.76; H, 5.36; F, 7.78; O, 13.10

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
5g USD 550.00 2 Weeks
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Related CAS #
5104-49-4 (free acid) 56767-76-1 (sodium)
Synonym
Flurbiprofen; Ansaid; Froben; Cebutid; Antadys; Flubiprofen; Flurbiprofene; Flurbiprofeno; NSC-757037; NSC 757037; NSC757037;
IUPAC/Chemical Name
2-(3-fluoro-4-phenylphenyl)propanoic acid
InChi Key
SYTBZMRGLBWNTM-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
SMILES Code
CC(C1=CC=C(C2=CC=CC=C2)C(F)=C1)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 244.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abdel-Aziz AA, Al-Badr AA, Hafez GA. Flurbiprofen. Profiles Drug Subst Excip Relat Methodol. 2012;37:113-81. doi: 10.1016/B978-0-12-397220-0.00004-0. Epub 2012 Mar 19. PMID: 22469318. 2: Flurbiprofen. Med Lett Drugs Ther. 1989 Apr 7;31(789):31-2. PMID: 2648127. 3: DeLia JE, Emery MG, Taylor RH, Scott JR. Flurbiprofen in dysmenorrhea. Clin Pharmacol Ther. 1982 Jul;32(1):76-80. doi: 10.1038/clpt.1982.129. PMID: 7083734. 4: Richy F, Rabenda V, Mawet A, Reginster JY. Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative. Int J Clin Pract. 2007 Aug;61(8):1396-406. doi: 10.1111/j.1742-1241.2007.01452.x. Epub 2007 Jun 26. PMID: 17596188. 5: Gulen M, Unver Koluman B, Avci A, Satar S. Flurbiprofen-Associated Hemolytic Anemia. Am J Ther. 2019 Nov/Dec;26(6):e723-e726. doi: 10.1097/MJT.0000000000000879. PMID: 30418224. 6: Davies NM. Clinical pharmacokinetics of flurbiprofen and its enantiomers. Clin Pharmacokinet. 1995 Feb;28(2):100-14. doi: 10.2165/00003088-199528020-00002. PMID: 7736686. 7: Zhang L, Xie J, Liu C, Sun Y, Zhang P. Comparison of percutaneous permeation profiles of flurbiprofen enantiomers. Chirality. 2022 Jun;34(6):894-900. doi: 10.1002/chir.23441. Epub 2022 Apr 12. PMID: 35411968. 8: Kaiser DG, Brooks CD, Lomen PL. Pharmacokinetics of flurbiprofen. Am J Med. 1986 Mar 24;80(3A):10-5. doi: 10.1016/0002-9343(86)90104-x. PMID: 3963013. 9: Zhang L, Zhu J, Xu L, Zhang X, Wang H, Luo Z, Zhao Y, Yu Y, Zhang Y, Shi H, Bao H. Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis. Med Sci Monit. 2014 Jun 17;20:995-1002. doi: 10.12659/MSM.890102. PMID: 24935068; PMCID: PMC4070992. 10: Geerts H. Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease. IDrugs. 2007 Feb;10(2):121-33. PMID: 17285465. 11: Brogden RN, Heel RC, Speight TM, Avery GS. Flurbiprofen: a review of its pharmacological properties and therapeutic use in rheumatic diseases. Drugs. 1979 Dec;18(6):417-38. doi: 10.2165/00003495-197918060-00001. PMID: 391529. 12: Solomon GD, Kunkel RS. Flurbiprofen in the prophylaxis of migraine. Cleve Clin J Med. 1993 Jan-Feb;60(1):43-8. doi: 10.3949/ccjm.60.1.43. PMID: 8443934. 13: Gasparini L, Ongini E, Wilcock D, Morgan D. Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain Res Brain Res Rev. 2005 Apr;48(2):400-8. doi: 10.1016/j.brainresrev.2004.12.029. Epub 2005 Jan 28. PMID: 15850679. 14: Huskisson EC, Scott PJ, Boyle S, Patrick M. Flurbiprofen at night. Curr Med Res Opin. 1977;5(1):85-7. doi: 10.1185/03007997709108982. PMID: 71974. 15: Wang RD, Sheng XR, Guan WX, Wang M, Peng C, Yang YY, Huang HG, Ning-Li, Jia WD. Flurbiprofen axetil for postoperative analgesia in upper abdominal surgery: a randomized, parallel controlled, double-blind, multicenter clinical study. Surg Today. 2020 Jul;50(7):749-756. doi: 10.1007/s00595-019-01951-1. Epub 2020 Jan 10. PMID: 31925579. 16: Cui X, Ding Q, Shan RN, He CH, Wu KJ. Enantioseparation of flurbiprofen enantiomers using chiral ionic liquids by liquid-liquid extraction. Chirality. 2019 Jun;31(6):457-467. doi: 10.1002/chir.23071. Epub 2019 May 7. PMID: 31062890. 17: Yi EM, Leech E. Topical flurbiprofen toxicosis in a cat. J Vet Emerg Crit Care (San Antonio). 2017 Nov;27(6):707-712. doi: 10.1111/vec.12638. Epub 2017 Aug 23. PMID: 28834579. 18: Paliwal S, Tilak A, Sharma J, Dave V, Sharma S, Yadav R, Patel S, Verma K, Tak K. Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model. Lipids Health Dis. 2019 Jun 7;18(1):133. doi: 10.1186/s12944-019-1064-x. PMID: 31170970; PMCID: PMC6554971. 19: Zhao X, Ji L. Flurbiprofen axetil: Analgesic effect and adverse reaction. Pak J Pharm Sci. 2018 May;31(3(Special)):1163-1167. PMID: 29735468. 20: Khan M, Alam A, Khan KM, Salar U, Chigurupati S, Wadood A, Ali F, Mohammad JI, Riaz M, Perveen S. Flurbiprofen derivatives as novel α-amylase inhibitors: Biology-oriented drug synthesis (BIODS), in vitro, and in silico evaluation. Bioorg Chem. 2018 Dec;81:157-167. doi: 10.1016/j.bioorg.2018.07.038. Epub 2018 Aug 2. PMID: 30125730.