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MedKoo Cat#: 576578 | Name: Dothiepin hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dothiepin hydrochloride is a tricyclic antidepressant with some tranquilizing action.

Chemical Structure

Dothiepin hydrochloride
Dothiepin hydrochloride
CAS#897-15-4

Theoretical Analysis

MedKoo Cat#: 576578

Name: Dothiepin hydrochloride

CAS#: 897-15-4

Chemical Formula: C19H22ClNS

Exact Mass: 331.1161

Molecular Weight: 331.90

Elemental Analysis: C, 68.76; H, 6.68; Cl, 10.68; N, 4.22; S, 9.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Depresym; Dosulepin chloride; Dosulepin hydrochloride; Dosulepin HCl; Dothiepin hydrochloride; Dothiepin HCl; Prothiaden; Xerenal
IUPAC/Chemical Name
1-Propanamine, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride
InChi Key
XUPZAARQDNSRJB-SJDTYFKWSA-N
InChi Code
InChI=1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
SMILES Code
Cl.CN(C)CC\C=C\1/c2ccccc2CSc3ccccc13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 331.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Lancaster SG, Gonzalez JP. Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Jul;38(1):123-47. doi: 10.2165/00003495-198938010-00005. PMID: 2670509. 2. Hayasaka Y, Purgato M, Magni LR, Ogawa Y, Takeshima N, Cipriani A, Barbui C, Leucht S, Furukawa TA. Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials. J Affect Disord. 2015 Jul 15;180:179-84. doi: 10.1016/j.jad.2015.03.021. Epub 2015 Mar 31. PMID: 25911132. 3. Donovan S, Dearden L, Richardson L. The tolerability of dothiepin: a review of clinical studies between 1963 and 1990 in over 13,000 depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov;18(7):1143-62. doi: 10.1016/0278-5846(94)90117-1. PMID: 7846285.