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MedKoo Cat#: 465297 | Name: Epimedin C
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Epimedin C is a flavonoid glycoside that has been found in E. koreanum and has diverse biological activities. It scavenges DPPH radicals in a cell-free assay (IC50 = 142 µM). Epimedin B increases proliferation of UMR-106 osteoblasts by 30.4 and 41.6% when used at concentrations of 0.1 and 10 µM, respectively.2 It inhibits ear edema induced by phorbol 12-myristate 13-acetate (TPA) in mice (ED50 = 192 nmol/ear).

Chemical Structure

Epimedin C
Epimedin C
CAS#110642-44-9

Theoretical Analysis

MedKoo Cat#: 465297

Name: Epimedin C

CAS#: 110642-44-9

Chemical Formula: C39H50O19

Exact Mass: 822.2946

Molecular Weight: 822.81

Elemental Analysis: C, 56.93; H, 6.13; O, 36.94

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
250mg USD 1,450.00 2 Weeks
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Synonym
Epimedin C; Epimedin-C; Epmedin C; Baohuoside VI; Baohuoside-VI;
IUPAC/Chemical Name
3-(((2S,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChi Key
ULZLIYVOYYQJRO-JIYCBSMMSA-N
InChi Code
InChI=1S/C39H50O19/c1-14(2)6-11-19-21(54-38-32(50)29(47)26(44)22(13-40)55-38)12-20(41)23-27(45)35(33(56-34(19)23)17-7-9-18(51-5)10-8-17)57-39-36(30(48)25(43)16(4)53-39)58-37-31(49)28(46)24(42)15(3)52-37/h6-10,12,15-16,22,24-26,28-32,36-44,46-50H,11,13H2,1-5H3/t15-,16-,22+,24-,25-,26+,28+,29-,30+,31+,32+,36+,37-,38+,39-/m0/s1
SMILES Code
C/C(C)=C\CC1=C2C(C(C(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)[C@H](O)[C@@H](O)[C@H](C)O3)=C(O2)C5=CC=C(OC)C=C5)=O)=C(O)C=C1O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 30.0 36.46
DMSO 30.0 36.46
PBS (pH 7.2) 1.0 1.22
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 822.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li J, Chen W, Wang Y, Yin H. An LC-MS/MS method for simultaneous quantification of 11 components of Xian-Xiong-Gu-Kang in the plasma of osteoarthritic rats and pharmacokinetic analysis. J Sep Sci. 2021 Jun 29. doi: 10.1002/jssc.202100132. Epub ahead of print. PMID: 34185967. 2: An HM, Li MN, Yang H, Pang HQ, Qu C, Xu Y, Liu RZ, Peng C, Li P, Gao W. A validated UHPLC-MS/MS method for pharmacokinetic and brain distribution studies of twenty constituents in rat after oral administration of Jia-Wei-Qi-Fu-Yin. J Pharm Biomed Anal. 2021 Aug 5;202:114140. doi: 10.1016/j.jpba.2021.114140. Epub 2021 May 13. PMID: 34015592. 3: Jiang H, Liu J, Wang Y, Chen L, Liu H, Wang Z, Wang B. Screening the Q-markers of TCMs from RA rat plasma using UHPLC-QTOF/MS technique for the comprehensive evaluation of Wu-Wei-Wen-Tong Capsule. J Mass Spectrom. 2021 May;56(5):e4711. doi: 10.1002/jms.4711. PMID: 33764633. 4: Hu Y, Wang Z, Xia F, Yang W, Liu YC, Wan JB. Simultaneous quantification of bioactive components in Chinese herbal spirits by ultra-high performance liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC-QQQ-MS/MS). Chin Med. 2021 Mar 12;16(1):26. doi: 10.1186/s13020-021-00435-0. PMID: 33712054; PMCID: PMC7953818. 5: Huang M, Wei Y, Dong J. Epimedin C modulates the balance between Th9 cells and Treg cells through negative regulation of noncanonical NF-κB pathway and MAPKs activation to inhibit airway inflammation in the ovalbumin-induced murine asthma model. Pulm Pharmacol Ther. 2020 Dec;65:102005. doi: 10.1016/j.pupt.2021.102005. Epub 2021 Feb 23. PMID: 33636365. 6: Shen Y, Wang M, Zhou J, Chen Y, Wu M, Yang Z, Yang C, Xia G, Tam JP, Zhou C, Yang H, Jia X. Construction of Fe3O4@α-glucosidase magnetic nanoparticles for ligand fishing of α-glucosidase inhibitors from a natural tonic Epimedii Folium. Int J Biol Macromol. 2020 Dec 15;165(Pt A):1361-1372. doi: 10.1016/j.ijbiomac.2020.10.018. Epub 2020 Oct 10. PMID: 33049236. 7: Li XM, Pan JQ, Luo YJ, Yang QR, Xu CQ, Shen GA, Wei SH, Guo BL. [Effects of light quality on growth and icariin flavonoid content of Epimedium pseudowushanense under different light intensity]. Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(11):2502-2508. Chinese. doi: 10.19540/j.cnki.cjcmm.20200329.113. PMID: 32627481. 8: Ziadlou R, Barbero A, Martin I, Wang X, Qin L, Alini M, Grad S. Anti- Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes. Biomolecules. 2020 Jun 19;10(6):932. doi: 10.3390/biom10060932. PMID: 32575510; PMCID: PMC7356262. 9: Zhou AZ, Wang L, Cheng B. [Ethanol extraction technology of Epimedii Folium and protective effect of ethanol extract on chondrocyte]. Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(5):1097-1104. Chinese. doi: 10.19540/j.cnki.cjcmm.20191221.309. PMID: 32237452. 10: Tang XY, Gao MX, Xiao HH, Yun WJ, Dai Y, Yao ZH, Wong MS, Yao XS. Simultaneous Quantitative Analysis of Multiple Biotransformation Products of Xian-Ling-Gu-Bao, a Traditional Chinese Medicine Prescription, with Rat Intestinal Microflora by Ultra-Performance Liquid Chromatography Tandem Triple Quadrupole Mass Spectrometry. J Chromatogr Sci. 2020 Jun 5;58(6):494-503. doi: 10.1093/chromsci/bmaa012. PMID: 32236407. 11: Ma JY, Shi XL, Liu L, Xu GL, Zhang JW. Evaluation of nine active components of Lu-Jiao Fang in normal and hypertrophic rat myocardia via LC-MS/MS. Biomed Chromatogr. 2020 May;34(5):e4814. doi: 10.1002/bmc.4814. Epub 2020 Mar 13. PMID: 32100317. 12: Yang XH, Li L, Xue YB, Zhou XX, Tang JH. Flavonoids from Epimedium pubescens: extraction and mechanism, antioxidant capacity and effects on CAT and GSH-Px of Drosophila melanogaster. PeerJ. 2020 Jan 20;8:e8361. doi: 10.7717/peerj.8361. PMID: 31998556; PMCID: PMC6977501. 13: Wang Y, Peng B, Zhao J, Wang M, Zhao L. Efficient extraction and determination of prenylflavonol glycosides in Epimedium pubescens Maxim. using deep eutectic solvents. Phytochem Anal. 2020 May;31(3):375-383. doi: 10.1002/pca.2904. Epub 2019 Nov 26. PMID: 31773856. 14: Huang X, Wang X, Zhang Y, Shen L, Wang N, Xiong X, Zhang L, Cai X, Shou D. Absorption and utilisation of epimedin C and icariin from Epimedii herba, and the regulatory mechanism via the BMP2/ Runx2 signalling pathway. Biomed Pharmacother. 2019 Oct;118:109345. doi: 10.1016/j.biopha.2019.109345. Epub 2019 Aug 19. PMID: 31545266. 15: Tang XY, Dai ZQ, Wu QC, Zeng JX, Gao MX, Xiao HH, Yao ZH, Dai Y, Yao XS. Simultaneous determination of multiple components in rat plasma and pharmacokinetic studies at a pharmacodynamic dose of Xian-Ling-Gu-Bao capsule by UPLC-MS/MS. J Pharm Biomed Anal. 2020 Jan 5;177:112836. doi: 10.1016/j.jpba.2019.112836. Epub 2019 Aug 26. PMID: 31473481. 16: Wei DH, Deng JL, Shi RZ, Ma L, Shen JM, Hoffman R, Hu YH, Wang H, Gao JL. Epimedin C Protects H2O2-Induced Peroxidation Injury by Enhancing the Function of Endothelial Progenitor HUVEC Populations. Biol Pharm Bull. 2019 Sep 1;42(9):1491-1499. doi: 10.1248/bpb.b19-00159. Epub 2019 Jun 14. PMID: 31204351. 17: Lyu Y, Zeng W, Du G, Chen J, Zhou J. Efficient bioconversion of epimedin C to icariin by a glycosidase from Aspergillus nidulans. Bioresour Technol. 2019 Oct;289:121612. doi: 10.1016/j.biortech.2019.121612. Epub 2019 Jun 6. PMID: 31203178. 18: Wang N, Xu P, Wang X, Yao W, Yu Z, Wu R, Huang X, Si Y, Shou D. Integrated pathological cell fishing and network pharmacology approach to investigate main active components of Er-Xian decotion for treating osteoporosis. J Ethnopharmacol. 2019 Sep 15;241:111977. doi: 10.1016/j.jep.2019.111977. Epub 2019 May 25. PMID: 31136804. 19: Zhong R, Chen Y, Ling J, Xia Z, Zhan Y, Sun E, Shi Z, Feng L, Jia X, Song J, Wei Y. The Toxicity and Metabolism Properties of Herba Epimedii Flavonoids on Laval and Adult Zebrafish. Evid Based Complement Alternat Med. 2019 Mar 3;2019:3745051. doi: 10.1155/2019/3745051. PMID: 30941194; PMCID: PMC6421038. 20: Zhang RT, Wu HN, Yu GH, Zhou YL, Jia XB, Feng L. [Effective components and signaling pathways of Epimedium brevicornumbased on network pharmacology]. Zhongguo Zhong Yao Za Zhi. 2018 Dec;43(23):4709-4717. Chinese. doi: 10.19540/j.cnki.cjcmm.20180905.001. PMID: 30717562.

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