MCC-134 | CAS#181238-67-5 | vascular relaxing agent

MedKoo Cat#: 562543 | Name: MCC-134

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MCC-134 is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel as vascular relaxing agent.

Chemical Structure

MCC-134

CAS#181238-67-5

Theoretical Analysis

MedKoo Cat#: 562543

Name: MCC-134

CAS#: 181238-67-5

Chemical Formula: C16H17N3OS

Exact Mass: 299.1092

Molecular Weight: 299.39

Elemental Analysis: C, 64.19; H, 5.72; N, 14.04; O, 5.34; S, 10.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MCC-134; MCC 134; MCC134

IUPAC/Chemical Name

1-[4-(1H-imidazol-1-yl)benzoyl]-N-methyl-cyclobutanecarbothioamide

InChi Key

TUMUOLDYJYUKOV-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H17N3OS/c1-17-15(21)16(7-2-8-16)14(20)12-3-5-13(6-4-12)19-10-9-18-11-19/h3-6,9-11H,2,7-8H2,1H3,(H,17,21)

SMILES Code

S=C(C1(C(C2=CC=C(N3C=CN=C3)C=C2)=O)CCC1)NC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 299.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yamamoto T, Takahara K, Inai T, Node K, Teramoto N. Molecular analysis of ATP-sensitive K(+) channel subunits expressed in mouse portal vein. Vascul Pharmacol. 2015 Dec;75:29-39. doi: 10.1016/j.vph.2015.06.018. Epub 2015 Jul 8. PubMed PMID: 26163942. 2: Iwasa K, Zhu HL, Shibata A, Maehara Y, Teramoto N. Molecular analysis of ATP-sensitive K⁺ channel subunits expressed in mouse vas deferens myocytes. Br J Pharmacol. 2014 Jan;171(1):145-57. doi: 10.1111/bph.12437. PubMed PMID: 24117345; PubMed Central PMCID: PMC3874703. 3: Naryzhnaia NV, Neckar J, Maslov LN, Lishmanov IuB, Kolar F, Lasukova TV. [The role of sarcolemmal and mitochondrial K(ATP)-channels in realization of the cardioprotection and antiarrhythmic effect of different regimens of hypobaric adaptation]. Ross Fiziol Zh Im I M Sechenova. 2009 Aug;95(8):837-49. Russian. PubMed PMID: 19803213. 4: Kolar F, Nekar J, Ostadal B, Maslov LN, Stakheev DL, Tayurskaya AS, Lishmanov YB. Role of ATP-sensitive K(+)-channels in antiarrhythmic and cardioprotective action of adaptation to intermittent hypobaric hypoxia. Bull Exp Biol Med. 2008 Apr;145(4):418-21. PubMed PMID: 19110582. 5: Kolár F, Neckár J, Ostádal B. MCC-134, a blocker of mitochondrial and opener of sarcolemmal ATP-sensitive K+ channels, abrogates cardioprotective effects of chronic hypoxia. Physiol Res. 2005;54(4):467-71. PubMed PMID: 16117602. 6: Yunoki T, Teramoto N, Takano N, Seki N, Creed KE, Naito S, Ito Y. The effects of MCC-134 on the ATP-sensitive K+ channels in pig urethra. Eur J Pharmacol. 2003 Dec 15;482(1-3):287-95. PubMed PMID: 14660034. 7: Yunoki T, Teramoto N, Ito Y. Functional involvement of sulphonylurea receptor (SUR) type 1 and 2B in the activity of pig urethral ATP-sensitive K+ channels. Br J Pharmacol. 2003 Jun;139(3):652-60. PubMed PMID: 12788825; PubMed Central PMCID: PMC1573868. 8: Sasaki N, Murata M, Guo Y, Jo SH, Ohler A, Akao M, O'Rourke B, Xiao RP, Bolli R, Marbán E. MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation. 2003 Mar 4;107(8):1183-8. PubMed PMID: 12615799; PubMed Central PMCID: PMC3680097. 9: Morita H, Yamada K, Abe K, Ito Y, Inoue R. Electrophysiological actions of a novel K(+) channel opener MCC-134 on rabbit portal vein smooth muscle. Eur J Pharmacol. 1999 Nov 19;384(2-3):203-12. PubMed PMID: 10611443. 10: Shindo T, Katayama Y, Horio Y, Kurachi Y. MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel. J Pharmacol Exp Ther. 2000 Jan;292(1):131-5. PubMed PMID: 10604939.

View History

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