Synonym
Quipazine maleate; MA 1291; MA1291; MA-1291
IUPAC/Chemical Name
2-(1-Piperazinyl)quinoline maleate
InChi Key
QYJJDHZHSCTBII-BTJKTKAUSA-N
InChi Code
InChI=1S/C13H15N3.C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
OC(/C=C\C(O)=O)=O.N1(c(cc2)nc3c2cccc3)CCNCC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
329.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mok E, Paquette M, Thibault L. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. doi: 10.1006/appe.2000.0321. PMID: 10888295.
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7: Bailey SP, Davis JM, Ahlborn EN. Neuroendocrine and substrate responses to altered brain 5-HT activity during prolonged exercise to fatigue. J Appl Physiol (1985). 1993 Jun;74(6):3006-12. doi: 10.1152/jappl.1993.74.6.3006. PMID: 8366000.
8: Bonson KR, Winter JC. Reversal of testosterone-induced dominance by the serotonergic agonist quipazine. Pharmacol Biochem Behav. 1992 Aug;42(4):809-13. doi: 10.1016/0091-3057(92)90034-d. PMID: 1513863.
9: Millan MJ, Bervoets K, Colpaert FC. 5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr- induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. J Pharmacol Exp Ther. 1991 Mar;256(3):973-82. PMID: 1826033.
10: Trubitsyna TK, Kashkovskiĭ MD. Farmakologicheskie svoĭstva nekotorykh indolilakil'nykh proizvodnykh kvipazina [Pharmacological properties of indolylalkyl derivatives of quipazine]. Farmakol Toksikol. 1980 Sep- Oct;43(5):530-6. Russian. PMID: 7449980.
