MedKoo Cat#: 556087 | Name: VUN73874
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VUN73874, also known as GOT1 inhibitor 2c, is a glutamate-​oxaloacetate transaminase 1 (GOT1)​ inhibitor. This compound was first reported in Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

VUN73874
VUN73874
CAS#732973-87-4

Theoretical Analysis

MedKoo Cat#: 556087

Name: VUN73874

CAS#: 732973-87-4

Chemical Formula: C19H19ClN4O

Exact Mass: 354.1247

Molecular Weight: 354.84

Elemental Analysis: C, 64.31; H, 5.40; Cl, 9.99; N, 15.79; O, 4.51

Price and Availability

Size Price Availability Quantity
200mg USD 1,950.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 6,950.00 2 Weeks
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Related CAS #
No Data
Synonym
GOT1 inhibitor 2c; VUN73874; VUN-73874; VUN 73874;
IUPAC/Chemical Name
N-(4-Chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
InChi Key
VVVZKBOSNCHQEJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19ClN4O/c20-14-4-6-15(7-5-14)22-19(25)24-12-10-23(11-13-24)18-3-1-2-17-16(18)8-9-21-17/h1-9,21H,10-13H2,(H,22,25)
SMILES Code
O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 354.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. doi: 10.1016/j.bmcl.2018.04.061. Epub 2018 Apr 27. PMID: 29731362; PMCID: PMC6119644.