Oxazosulfyl | CAS#1616678-32-0 | Insecticide

MedKoo Cat#: 145185 | Name: Oxazosulfyl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxazosulfyl is part of a sulfyl class of insecticides with a potent and cross-spectrum insecticidal activity. Oxazosulfyl controls for a wide range of insect pests of rice. Oxazosulfyl was previously shown to stabilise voltage-gated sodium channels in their slow-inactivated conformation with an IC50 value of 12.3μM.

Chemical Structure

Oxazosulfyl

CAS#1616678-32-0

Theoretical Analysis

MedKoo Cat#: 145185

Name: Oxazosulfyl

CAS#: 1616678-32-0

Chemical Formula: C15H11F3N2O5S2

Exact Mass: 420.0061

Molecular Weight: 420.38

Elemental Analysis: C, 42.86; H, 2.64; F, 13.56; N, 6.66; O, 19.03; S, 15.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Oxazosulfyl;

IUPAC/Chemical Name

2-(3-(ethylsulfonyl)pyridin-2-yl)-5-((trifluoromethyl)sulfonyl)benzo[d]oxazole

InChi Key

PTQBEFQWTBZMED-UHFFFAOYSA-N

InChi Code

1S/C15H11F3N2O5S2/c1-2-26(21,22)12-4-3-7-19-13(12)14-20-10-8-9(5-6-11(10)25-14)27(23,24)15(16,17)18/h3-8H,2H2,1H3

SMILES Code

CCS(=O)(=O)C1=C(N=CC=C1)C2=NC3=CC(=CC=C3O2)S(=O)(=O)C(F)(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 420.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Suzuki T, Yamato S. Oxazosulfyl, a Novel Sulfyl Insecticide, Binds to and Stabilizes the Voltage-Gated Sodium Channels in the Slow-Inactivated State. J Agric Food Chem. 2021 Apr 14;69(14):4048-4055. doi: 10.1021/acs.jafc.0c04617. Epub 2021 Apr 1. PMID: 33793218. 2: Kamezaki M, Otsuki J, Natsuhara K. Insecticidal activity against rice pest of oxazosulfyl, a novel sulfyl insecticide. J Pestic Sci. 2024 Feb 20;49(1):31-37. doi: 10.1584/jpestics.D23-057. PMID: 38450091; PMCID: PMC10912969. 3: Xu L, Quan X, Li Z, Maienfisch P. Synthesis and Biological Activity of Silicon-Containing Ethylsulfonylpyridine Insecticides. J Agric Food Chem. 2023 Nov 29;71(47):18250-18259. doi: 10.1021/acs.jafc.3c04058. Epub 2023 Sep 6. PMID: 37672484. 4: Goodchild J, Chen YJ, Blythe J, Firth LC, Hirst E, Bess K, Bristow J, Willis J, Baines R, Cash F, Muehlebach M, Buchholz A, Rendler S, Earley F, Crossthwaite A. A novel class of insecticidal alkylsulfones are potent inhibitors of vesicular acetylcholine transport. Pestic Biochem Physiol. 2024 May;201:105854. doi: 10.1016/j.pestbp.2024.105854. Epub 2024 Mar 12. PMID: 38685234. 5: Lees R, Praulins G, Davies R, Brown F, Parsons G, White A, Ranson H, Small G, Malone D. A testing cascade to identify repurposed insecticides for next- generation vector control tools: screening a panel of chemistries with novel modes of action against a malaria vector. Gates Open Res. 2019 Jul 10;3:1464. doi: 10.12688/gatesopenres.12957.2. PMID: 31259317; PMCID: PMC6556762.