Oxolamine citrate | CAS# 1949-20-8 | Biochemical

MedKoo Cat#: 573954 | Name: Oxolamine citrate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxolamine citrate is a antiinflammatory drug used as a cough suppressant.

Chemical Structure

Oxolamine citrate

CAS#1949-20-8 (citrate)

Theoretical Analysis

MedKoo Cat#: 573954

Name: Oxolamine citrate

CAS#: 1949-20-8 (citrate)

Chemical Formula: C20H27N3O8

Exact Mass: 437.1798

Molecular Weight: 437.45

Elemental Analysis: C, 54.91; H, 6.22; N, 9.61; O, 29.26

Price and Availability

Size	Price	Availability	Quantity
25g	USD 450.00	2 weeks

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Related CAS #

1219-20-1 (HCl) 1949-20-8 (citrate) 959-14-8

Synonym

AF 438, AF438, AF-438, Oxolamine citrate, Oxolamine dihydrogen citrate

IUPAC/Chemical Name

1,2,4-Oxadiazole, 5-(2-(diethylamino)ethyl)-3-phenyl-, citrate

InChi Key

RBZIGQJSMCOHSS-UHFFFAOYSA-N

InChi Code

1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES Code

c1(c2ccccc2)nc(CC[NH+](CC)CC)on1.C([C@@](CC(=O)[O-])(C(O)=O)O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Oxolamine citrate is a antiinflammatory drug used as a cough suppressant.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	93.5	213.74
	Water	28.7	65.48

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 437.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Wang XQ, Wang XM, Zhou TF, Dong LQ. Screening of differentially expressed genes and small molecule drugs of pediatric allergic asthma with DNA microarray. Eur Rev Med Pharmacol Sci. 2012 Dec;16(14):1961-6. PubMed PMID: 23242723. 2: Zhu X, Lee DY, Shin WG. Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharm Drug Dispos. 2007 Apr;28(3):125-33. PubMed PMID: 17295362. 3: Min KA, Zhu X, Oh JM, Shin WG. Effect of oxolamine on anticoagulant effect of warfarin. Am J Health Syst Pharm. 2006 Jan 15;63(2):153-6. PubMed PMID: 16390929. 4: Ceyhan BB, Karakurt S. Effect of oxolamine on cough sensitivity in COPD patients. Respir Med. 2002 Jan;96(1):61-3. PubMed PMID: 11863211. 5: Kirilmaz L, Kendirci A, Güneri T. Sustained-release dosage form of oxolamine citrate: preparation and release kinetics. J Microencapsul. 1992 Apr-Jun;9(2):167-72. PubMed PMID: 1593399.