S07-1066 | Aldo-Keto Reductase 1C3 | AKR1C3 | Inhibitor

MedKoo Cat#: 124132 | Name: S07-1066

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S07-1066 is an Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitor for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. S07-1066 selectively blocked AKR1C3-mediated reduction of doxorubicin (DOX) in MCF-7 transfected cell models. Furthermore, co-treatment of S07-1066 significantly synergized DOX cytotoxicity and reversed the DOX resistance in MCF-7 cells overexpressing AKR1C3. The potential synergism of S07-1066 over DOX cytotoxicity was demonstrated in vitro and in vivo.

Chemical Structure

S07-1066

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124132

Name: S07-1066

CAS#: N/A

Chemical Formula: C16H11Cl2FO2

Exact Mass: 324.0100

Molecular Weight: 325.16

Elemental Analysis: C, 59.10; H, 3.41; Cl, 21.80; F, 5.84; O, 9.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

S07-1066; S071066; S07 1066

IUPAC/Chemical Name

1-(3',5'-dichloro-2-fluoro-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

InChi Key

DFJGLZRYGZSQOR-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H11Cl2FO2/c17-11-5-9(6-12(18)8-11)13-2-1-10(7-14(13)19)16(3-4-16)15(20)21/h1-2,5-8H,3-4H2,(H,20,21)

SMILES Code

ClC1=CC(C2=CC=C(C3(C(O)=O)CC3)C=C2F)=CC(Cl)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 325.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

He S, Chu X, Wu Y, Jiang J, Fang P, Chen Y, Liu Y, Qiu Z, Xiao Y, Li Z, Pan D, Zhang Q, Xie H, Xing S, Feng F, Liu W, Guo Q, Zhao L, Yang P, Sun H. Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J Med Chem. 2023 Jul 6. doi: 10.1021/acs.jmedchem.3c00213. Epub ahead of print. PMID: 37409679.