Synonym
Quipazine dimaleate; Quizapine
IUPAC/Chemical Name
2-(1-Piperazinyl)quinoline dimaleate
InChi Key
VAOSOCRJSSWBEQ-SPIKMXEPSA-N
InChi Code
InChI=1S/C13H15N3.2C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;2*5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
SMILES Code
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C1CN(CCN1)C1=NC2=C(C=CC=C2)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in water
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Quipazine dimaleate is a salt.
In vitro activity:
To be determined
In vivo activity:
Macronutrient intakes, 2h and 12h, following administration of quipazine were examined in three groups of adult male and female Wistar rats. Quipazine injection reduced carbohydrate ingestion from corn starch-containing diets in male and female rats. This study found that the nature of the macronutrient source is important to assess the effect of a drug on nutrient-specific selection.
Reference: Appetite. 2000 Jun;34(3):313-25. https://pubmed.ncbi.nlm.nih.gov/10888295/
|
Solvent |
mg/mL |
mM |
| Solubility |
| Water |
44.5 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
445.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Mok E, Paquette M, Thibault L. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. doi: 10.1006/appe.2000.0321. PMID: 10888295.
2. Bonson KR, Winter JC. Reversal of testosterone-induced dominance by the serotonergic agonist quipazine. Pharmacol Biochem Behav. 1992 Aug;42(4):809-13. doi: 10.1016/0091-3057(92)90034-d. PMID: 1513863.
In vivo protocol:
1. Mok E, Paquette M, Thibault L. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. doi: 10.1006/appe.2000.0321. PMID: 10888295.
2. Bonson KR, Winter JC. Reversal of testosterone-induced dominance by the serotonergic agonist quipazine. Pharmacol Biochem Behav. 1992 Aug;42(4):809-13. doi: 10.1016/0091-3057(92)90034-d. PMID: 1513863.
1: Mok E, Paquette M, Thibault L. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. doi: 10.1006/appe.2000.0321. PMID: 10888295.
2: Wolf A, Jackson A, Price T, Trevino A, Caldarola-Pastuszka M, Uphouse L. Attenuation of the lordosis-inhibiting effects of 8-OH-DPAT by TFMPP and quipazine. Brain Res. 1998 Sep 7;804(2):206-11. doi: 10.1016/s0006-8993(98)00625-8. PMID: 9757039.
3: Wolf A, Caldarola-Pastuszka M, Uphouse L. Facilitation of female rat lordosis behavior by hypothalamic infusion of 5-HT(2A/2C) receptor agonists. Brain Res. 1998 Jan 1;779(1-2):84-95. doi: 10.1016/s0006-8993(97)01082-2. PMID: 9473601.
4: Saruhashi Y, Young W, Sugimori M, Abrahams J, Sakuma J. Evidence for serotonin sensitivity of adult rat spinal axons: studies using randomized double pulse stimulation. Neuroscience. 1997 Sep;80(2):559-66. doi: 10.1016/s0306-4522(96)00708-7. PMID: 9284357.
5: Saruhashi Y, Young W, Hassan AZ, Park R. Excitatory and inhibitory effects of serotonin on spinal axons. Neuroscience. 1994 Aug;61(3):645-53. doi: 10.1016/0306-4522(94)90441-3. PMID: 7969935.
6: Bailey SP, Davis JM, Ahlborn EN. Serotonergic agonists and antagonists affect endurance performance in the rat. Int J Sports Med. 1993 Aug;14(6):330-3. doi: 10.1055/s-2007-1021187. PMID: 8407063.
7: Bailey SP, Davis JM, Ahlborn EN. Neuroendocrine and substrate responses to altered brain 5-HT activity during prolonged exercise to fatigue. J Appl Physiol (1985). 1993 Jun;74(6):3006-12. doi: 10.1152/jappl.1993.74.6.3006. PMID: 8366000.
8: Bonson KR, Winter JC. Reversal of testosterone-induced dominance by the serotonergic agonist quipazine. Pharmacol Biochem Behav. 1992 Aug;42(4):809-13. doi: 10.1016/0091-3057(92)90034-d. PMID: 1513863.
9: Millan MJ, Bervoets K, Colpaert FC. 5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr- induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. J Pharmacol Exp Ther. 1991 Mar;256(3):973-82. PMID: 1826033.
10: Trubitsyna TK, Kashkovskiĭ MD. Farmakologicheskie svoĭstva nekotorykh indolilakil'nykh proizvodnykh kvipazina [Pharmacological properties of indolylalkyl derivatives of quipazine]. Farmakol Toksikol. 1980 Sep- Oct;43(5):530-6. Russian. PMID: 7449980.
