Synonym
Racepinephrine Free Base; CCRIS8140; CCRIS-8140; CCRIS 8140
IUPAC/Chemical Name
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-
InChi Key
UCTWMZQNUQWSLP-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3
SMILES Code
OC1=CC=C(C(O)CNC)C=C1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
183.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Petrocheilou A, Tanou K, Kalampouka E, Malakasioti G, Giannios C, Kaditis AG. Viral croup: diagnosis and a treatment algorithm. Pediatr Pulmonol. 2014 May;49(5):421-9. doi: 10.1002/ppul.22993. Epub 2014 Mar 5. PMID: 24596395.
2: Bjornson C, Russell K, Vandermeer B, Klassen TP, Johnson DW. Nebulized epinephrine for croup in children. Cochrane Database Syst Rev. 2013 Oct 10;(10):CD006619. doi: 10.1002/14651858.CD006619.pub3. PMID: 24114291.
3: Mondal P, Kandala B, Ahrens R, Chesrown SE, Hendeles L. Nonprescription racemic epinephrine for asthma. J Allergy Clin Immunol Pract. 2014 Sep- Oct;2(5):575-8. doi: 10.1016/j.jaip.2014.02.014. Epub 2014 Apr 18. PMID: 25213051.
4: Larson TA, Uden DL, Schilling CG. Stability of epinephrine hydrochloride in an extemporaneously compounded topical anesthetic solution of lidocaine, racepinephrine, and tetracaine. Am J Health Syst Pharm. 1996 Mar 15;53(6):659-62. doi: 10.1093/ajhp/53.6.659. PMID: 8800972.
5: Skolnik N. Croup. J Fam Pract. 1993 Aug;37(2):165-70. PMID: 8336098.
6: Asmundsson AS, Arms J, Kaila R, Roback MG, Theiler C, Davey CS, Louie JP. Hospital Course of Croup After Emergency Department Management. Hosp Pediatr. 2019 May;9(5):326-332. doi: 10.1542/hpeds.2018-0066. PMID: 30988017; PMCID: PMC6478427.
7: Food and Drug Administration, HHS. Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule. Fed Regist. 2011 Jul 26;76(143):44475-89. PMID: 21796845.
8: Chiang E, Afandi O, Lee SH, Suresh S, Pitetti RD, Ramgopal S. Inpatient use of racemic epinephrine for children admitted with croup. World J Pediatr. 2019 Dec;15(6):586-594. doi: 10.1007/s12519-019-00291-x. Epub 2019 Jul 25. PMID: 31342466.
9: Brown JC. The management of croup. Br Med Bull. 2002;61:189-202. doi: 10.1093/bmb/61.1.189. PMID: 11997306.
10: Johnson DW, Jacobson S, Edney PC, Hadfield P, Mundy ME, Schuh S. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup. N Engl J Med. 1998 Aug 20;339(8):498-503. doi: 10.1056/NEJM199808203390802. PMID: 9709042.