CZY-1068 | EP2/EP4 Dual Antagonist

MedKoo Cat#: 128308 | Name: CZY-1068

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CZY-1068 is an EP2/EP4 Dual Antagonist. CZY-1068 significantly reduced PGE2-induced expression of immune suppression related genes in macrophages. Notably, CZY-1068 elicited robust antitumor efficacy in the syngeneic MC38 tumor model.

Chemical Structure

CZY-1068

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128308

Name: CZY-1068

CAS#: N/A

Chemical Formula: C31H24FNO5S

Exact Mass: 541.1359

Molecular Weight: 541.59

Elemental Analysis: C, 68.75; H, 4.47; F, 3.51; N, 2.59; O, 14.77; S, 5.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CZY-1068; CZY1068; CZY 1068

IUPAC/Chemical Name

4-((2-(4-(benzofuran-5-yl)-3-fluorobenzyl)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxamido)methyl)benzoic acid

InChi Key

CETFDWKBAAUQHG-UHFFFAOYSA-N

InChi Code

InChI=1S/C31H24FNO5S/c32-25-13-19(3-7-23(25)21-6-8-26-22(15-21)9-12-38-26)14-27-29(24-10-11-37-17-28(24)39-27)30(34)33-16-18-1-4-20(5-2-18)31(35)36/h1-9,12-13,15H,10-11,14,16-17H2,(H,33,34)(H,35,36)

SMILES Code

O=C(NCC1=CC=C(C(O)=O)C=C1)C2=C(CC3=CC=C(C4=CC=C(OC=C5)C5=C4)C(F)=C3)SC6=C2CCOC6

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 541.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Cheng Z, Zhang Y, Du L, Wang W, Chai X, He M, Zhang H, Wu D, Lu J, Zhang S, Feng B, Yang L, Liu M, Lu W. Subtle Structural Modifications Spanning from EP4 Antagonism to EP2/EP4 Dual Antagonism: A Novel Class of Thienocyclic-Based Derivatives. J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02241. Epub ahead of print. PMID: 39757828.