N-(4,6-divinyl-1,3,5-triazin-2-yl)-PEG4-acid is a novel cysteine binder coupled to a terminal carboxylic acid bound by a PEG linker. The divinyltriazine works by stapling of two cysteine residues to form macrocyclic peptides from their unprotected linear counterparts. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
MedKoo Cat#: 122095
Name: N-(4,6-divinyl-1,3,5-triazin-2-yl)-PEG4-acid
CAS#: N/A
Chemical Formula: C21H33N5O7
Exact Mass: 467.2380
Molecular Weight: 467.52
Elemental Analysis: C, 53.95; H, 7.11; N, 14.98; O, 23.95
The following data is based on the product molecular weight 467.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
