Vandetanib Fumarate | CAS#338992-00-0 | tyrosine kinase inhibitor

MedKoo Cat#: 558309 | Name: Vandetanib fumarate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vandetanib Fumarate is a once-daily orally available tyrosine kinase inhibitor that works by blocking RET (REarranged during Transfection), vascular endothelial growth factor receptor (VEGFR-2, VEGFR-3), and epidermal growth factor receptor and to a lesser extent VEGFR-1, which are important targets in thyroid cancer (TC). It is emerging as a potentially effective option in the treatment of advanced medullary thyroid cancer (MTC) and in dedifferentiated papillary thyroid cancer not responsive to radioiodine.

Chemical Structure

Vandetanib fumarate

CAS#338992-00-0 (fumarate)

Theoretical Analysis

MedKoo Cat#: 558309

Name: Vandetanib fumarate

CAS#: 338992-00-0 (fumarate)

Chemical Formula: C26H28BrFN4O6

Exact Mass: 0.0000

Molecular Weight: 591.43

Elemental Analysis: C, 52.80; H, 4.77; Br, 13.51; F, 3.21; N, 9.47; O, 16.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

443913-73-3 (free base) 338992-00-0 (fumarate)

Synonym

Vandetanib Fumarate; Vandetanib; Caprelsa; HSDB 8198; Zactima; ZD 6474; ZD6474

IUPAC/Chemical Name

N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine Fumarate

InChi Key

NEJYMTWEAISFSJ-WLHGVMLRSA-N

InChi Code

InChI=1S/C22H24BrFN4O2.C4H4O4/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24;5-3(6)1-2-4(7)8/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27);1-2H,(H,5,6)(H,7,8)/b;2-1+

SMILES Code

CN1CCC(COC2=CC3=NC=NC(NC4=CC=C(Br)C=C4F)=C3C=C2OC)CC1.O=C(O)/C=C/C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 591.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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