MedKoo Cat#: 576283 | Name: Hexamethonium chloride dihydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hexamethonium chloride dihydrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant.

Chemical Structure

Hexamethonium chloride dihydrate
Hexamethonium chloride dihydrate
CAS#16986-49-5 (chloride dihydrate)

Theoretical Analysis

MedKoo Cat#: 576283

Name: Hexamethonium chloride dihydrate

CAS#: 16986-49-5 (chloride dihydrate)

Chemical Formula: C12H34Cl2N2O2

Exact Mass: 0.0000

Molecular Weight: 309.32

Elemental Analysis: C, 46.60; H, 11.08; Cl, 22.92; N, 9.06; O, 10.34

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 550.00 2 Weeks
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Synonym
Hexamethonium chloride dihydrate
IUPAC/Chemical Name
1,6-Hexanediaminium,N1,N1,N1,N6,N6,N6-hexamethyl-, chloride, hydrate (1:2:2)
InChi Key
HQDLRYUQFUBIHD-UHFFFAOYSA-L
InChi Code
InChI=1S/C12H30N2.2ClH.2H2O/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2
SMILES Code
O.O.[Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: AUBERT H, GAVRILESCU S. [Hexamethonium bromide in therapy of some cardiovascular diseases]. Med Interna (Bucur). 1956 Dec;8(8):1182-9. Romanian. PubMed PMID: 13418082. 2: O'Byrne PM, Thomson NC, Latimer KM, Roberts RS, Morris MM, Daniel EE, Hargreave FE. The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine. J Allergy Clin Immunol. 1985 Jul;76(1):97-103. PubMed PMID: 2861223. 3: GILMORE HR, KOPELMAN H, MCMICHAEL J, MILNE IG. The effect of hexamethonium bromide on the cardiac output and pulmonary circulation. Lancet. 1952 Nov 8;2(6741):898-902. PubMed PMID: 12991634. 4: HUNTER AR. Hexamethonium bromide. Lancet. 1950 Feb 11;1(6598):251. PubMed PMID: 15403290. 5: Sun HZ, Zhao SZ, Ai HB. Microinjection of l-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor - nitric oxide pathway. Can J Physiol Pharmacol. 2014 Jun;92(6):455-9. doi: 10.1139/cjpp-2013-0413. Epub 2014 Apr 3. PubMed PMID: 24830549.