Hexamethonium bromide dihydrate | CAS# 5187-74-6 | Biochemical

MedKoo Cat#: 576282 | Name: Hexamethonium bromide dihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hexamethonium bromide dihydrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant.

Chemical Structure

Hexamethonium bromide dihydrate

CAS#5187-74-6 (bromide dihydrate)

Theoretical Analysis

MedKoo Cat#: 576282

Name: Hexamethonium bromide dihydrate

CAS#: 5187-74-6 (bromide dihydrate)

Chemical Formula: C12H34Br2N2O2

Exact Mass: 0.0000

Molecular Weight: 398.22

Elemental Analysis: C, 36.19; H, 8.61; Br, 40.13; N, 7.03; O, 8.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

60-26-4 (cation) 55-97-0 (bromide) 5187-74-6 (bromide dihydrate) 60-25-3 (chloride) 16986-49-5 (chloride dihydrate) 815-76-9 (monotartrate) 2079-78-9 (tartrate)

Synonym

Hexamethonium bromide dihydrate; Hexamethonium dibromide dihydrate

IUPAC/Chemical Name

1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide, hydrate (1:2:2)

InChi Key

FLMOMVBGUCEQEW-UHFFFAOYSA-L

InChi Code

InChI=1S/C12H30N2.2BrH.2H2O/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2

SMILES Code

O.O.[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 398.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: AUBERT H, GAVRILESCU S. [Hexamethonium bromide in therapy of some cardiovascular diseases]. Med Interna (Bucur). 1956 Dec;8(8):1182-9. Romanian. PubMed PMID: 13418082. 2: O'Byrne PM, Thomson NC, Latimer KM, Roberts RS, Morris MM, Daniel EE, Hargreave FE. The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine. J Allergy Clin Immunol. 1985 Jul;76(1):97-103. PubMed PMID: 2861223. 3: GILMORE HR, KOPELMAN H, MCMICHAEL J, MILNE IG. The effect of hexamethonium bromide on the cardiac output and pulmonary circulation. Lancet. 1952 Nov 8;2(6741):898-902. PubMed PMID: 12991634. 4: HUNTER AR. Hexamethonium bromide. Lancet. 1950 Feb 11;1(6598):251. PubMed PMID: 15403290. 5: Sun HZ, Zhao SZ, Ai HB. Microinjection of l-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor - nitric oxide pathway. Can J Physiol Pharmacol. 2014 Jun;92(6):455-9. doi: 10.1139/cjpp-2013-0413. Epub 2014 Apr 3. PubMed PMID: 24830549.