CAM741 | CAS#177586-74-2 | VCAM1 synthesis inhibitor

MedKoo Cat#: 465358 | Name: CAM741

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CAM741 is a novel selective inhibitor of vascular cell adhesion molecule 1 (VCAM1) synthesis in endothelial cells, blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1.

Chemical Structure

CAM741

CAS#177586-74-2

Theoretical Analysis

MedKoo Cat#: 465358

Name: CAM741

CAS#: 177586-74-2

Chemical Formula: C56H91N7O11

Exact Mass: 1037.6777

Molecular Weight: 1038.38

Elemental Analysis: C, 64.78; H, 8.83; N, 9.44; O, 16.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CAM741; CAM 741; CAM-741;

IUPAC/Chemical Name

propyl 3-((2R,5S,8S,11S,14S,17S,20S)-8,11-diisobutyl-14-((1-methoxy-1H-indol-3-yl)methyl)-7,13,19,20-tetramethyl-5,17-bis((R)-2-methylhexyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclohenicosan-2-yl)propanoate

InChi Key

VDFZHYIUDDBVPN-IVUNSTSTSA-N

InChi Code

InChI=1S/C56H91N7O11/c1-15-18-22-37(8)31-43-53(68)60(11)39(10)56(71)74-48(26-27-49(64)73-28-17-3)52(67)59-44(32-38(9)23-19-16-2)55(70)61(12)46(30-36(6)7)50(65)57-42(29-35(4)5)54(69)62(13)47(51(66)58-43)33-40-34-63(72-14)45-25-21-20-24-41(40)45/h20-21,24-25,34-39,42-44,46-48H,15-19,22-23,26-33H2,1-14H3,(H,57,65)(H,58,66)(H,59,67)/t37-,38-,39+,42+,43+,44+,46+,47+,48-/m1/s1

SMILES Code

O=C(OCCC)CC[C@H](C(N[C@@H](C[C@H](C)CCCC)C(N(C)[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N(C)[C@@H](CC1=CN(OC)C2=C1C=CC=C2)C(N[C@@H](C[C@H](C)CCCC)C(N(C)[C@H]3C)=O)=O)=O)=O)=O)=O)OC3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,038.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schorr S, Nguyen D, Haßdenteufel S, Nagaraj N, Cavalié A, Greiner M, Weissgerber P, Loi M, Paton AW, Paton JC, Molinari M, Förster F, Dudek J, Lang S, Helms V, Zimmermann R. Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import. FEBS J. 2020 Nov;287(21):4612-4640. doi: 10.1111/febs.15274. Epub 2020 Mar 20. PMID: 32133789. 2: Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R. Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122. PMID: 29719251; PMCID: PMC5946456. 3: Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R. Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin. J Biol Chem. 2011 Oct 14;286(41):35588-35600. doi: 10.1074/jbc.M111.239244. Epub 2011 Jul 30. PMID: 21808059; PMCID: PMC3195616. 4: Harant H, Wolff B, Schreiner EP, Oberhauser B, Hofer L, Lettner N, Maier S, de Vries JE, Lindley IJ. Inhibition of vascular endothelial growth factor cotranslational translocation by the cyclopeptolide CAM741. Mol Pharmacol. 2007 Jun;71(6):1657-65. doi: 10.1124/mol.107.034249. Epub 2007 Mar 16. PMID: 17369307. 5: Harant H, Lettner N, Hofer L, Oberhauser B, de Vries JE, Lindley IJ. The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon. J Biol Chem. 2006 Oct 13;281(41):30492-502. doi: 10.1074/jbc.M607243200. Epub 2006 Aug 16. PMID: 16914554. 6: Besemer J, Harant H, Wang S, Oberhauser B, Marquardt K, Foster CA, Schreiner EP, de Vries JE, Dascher-Nadel C, Lindley IJ. Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Nature. 2005 Jul 14;436(7048):290-3. doi: 10.1038/nature03670. PMID: 16015337.