Trolox | CAS#53188-07-1 | antioxidant

MedKoo Cat#: 561324 | Name: Trolox

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trolox is an antioxidant like vitamin E and it is used to reduce oxidative stress or damage. Trolox is also used as a benchmark to assess the potency of other antioxidants. Trolox equivalent antioxidant capacity (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE).

Chemical Structure

Trolox

CAS#53188-07-1

Theoretical Analysis

MedKoo Cat#: 561324

Name: Trolox

CAS#: 53188-07-1

Chemical Formula: C14H18O4

Exact Mass: 250.1205

Molecular Weight: 250.29

Elemental Analysis: C, 67.18; H, 7.25; O, 25.57

Price and Availability

Size	Price	Availability	Quantity
500mg	USD 400.00	2 Weeks
1g	USD 600.00	2 Weeks

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Related CAS #

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Synonym

Trolox;

IUPAC/Chemical Name

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

InChi Key

GLEVLJDDWXEYCO-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)

SMILES Code

O=C(C1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 250.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Search: Trolox From: evan.izzo@medkoo.com 20 selected items PubMed Results Items 1-20 of 20 (Display the 20 citations in PubMed) 1: Liu F, Zhu Z, Zou H, Huang Z, Xiao S, Li Z. Novel Insights from Comprehensive Bioinformatics Analysis Utilizing Large-Scale Human Transcriptomes and Experimental Validation: The Role of Autophagy in Periodontitis. J Inflamm Res. 2024 Dec 30;17:11861-11880. doi: 10.2147/JIR.S492048. PMID: 39758938; PMCID: PMC11697667. 2: Hay TO, Fitzgerald MA, Nastasi JR. Systematic application of UPLC-Q-ToF-MS/MS coupled with chemometrics for the identification of natural food pigments from Davidson plum and native currant. Food Chem X. 2024 Dec 7;25:102072. doi: 10.1016/j.fochx.2024.102072. PMID: 39758069; PMCID: PMC11699109. 3: Vlocskó RB, Mastyugin M, Török B, Török M. Correlation of physicochemical properties with antioxidant activity in phenol and thiophenol analogues. Sci Rep. 2025 Jan 2;15(1):73. doi: 10.1038/s41598-024-83982-4. PMID: 39747219; PMCID: PMC11697322. 4: Zhou JJ, Yang L, Ma QY, Xie QY, Dai HF, Liu YH, You-Xing Z. Cochliomycin H, a new 12-membered resorcylic acid lactone from sponge-derived fungus Curvularia sp. ZYX-Z-4. Nat Prod Res. 2025 Jan 1:1-5. doi: 10.1080/14786419.2024.2448206. Epub ahead of print. PMID: 39743781. 5: Jaradat N, Hawash M, Ghanim M, Alqub M, Rabayaa M, Dwikat M, Issa L, Hussein F, Asadi L, Yassin L, Rabee H, Gamhur A. Phytochemical composition and antidiabetic, anti-obesity, antioxidant, and cytotoxic activities of Carthamus tinctorius seed oil. Sci Rep. 2024 Dec 28;14(1):31399. doi: 10.1038/s41598-024-83008-z. PMID: 39732883; PMCID: PMC11682395. 6: Osipova VP, Kolyada MN, Polovinkina MA, Kolumbet AD, Ponomareva EN, Velikorodov AV. Antioxidant activity and protective effect of hydroxy derivatives of chalcones for sterlet (Acipenser ruthenus, Linnaeus, 1758) sperm. Cryobiology. 2025 Jan 1;118:105193. doi: 10.1016/j.cryobiol.2024.105193. Epub ahead of print. PMID: 39725257. 7: Xue GM, Xue JF, Pan H, Feng H, Lei JW, Chen H, Feng WS, Li GS, Wang Y. Phenylpropanoid dimers from Chrysanthemum indicum with antioxidant effects via activating the Nrf2 signaling pathway. Phytochemistry. 2024 Dec 24;232:114372. doi: 10.1016/j.phytochem.2024.114372. Epub ahead of print. PMID: 39725186. 8: Şener L, Özdemir S, Yalçın MS, Gülcan M, Dizge N. Antibacterial activity of copper-decorated CeO2 nanoparticles and preparation of antifouling polyethersulfone surface. Heliyon. 2024 Nov 29;10(23):e40818. doi: 10.1016/j.heliyon.2024.e40818. PMID: 39717578; PMCID: PMC11665354. 9: Boruah JLH, Gogoi M, Famhawite V, Barman D, Das DJ, Puro KN, Biswas A, Mridha P, Gogoi P, Gajbhiye R, Baishya R. Phytochemical Characterization, Prooxidant, Antiproliferative and Anti-Inflammatory Potential of Meyna spinosa Roxb. Ex Link Ripe Fruit. Chem Biodivers. 2024 Dec 23:e202402342. doi: 10.1002/cbdv.202402342. Epub ahead of print. PMID: 39715024. 10: Wang Y, DU JF, Chen HP, Xu XF, Zhang XY. [Two new phenolic glucosides with antioxidant activity from Lythrum salicaria]. Zhongguo Zhong Yao Za Zhi. 2024 Nov;49(21):5914-5918. Chinese. doi: 10.19540/j.cnki.cjcmm.20240809.201. PMID: 39701801. 11: Coutinho RMP, Rocha JCG, Neves N, da Silva VLD, Seixas VNC, Hermosín- Gutiérrez I, de Carvalho AF, Stringheta PC. The nutritional profile comparison between the white and purple Açaí in the mesoregions of Pará, Brazil. Front Nutr. 2024 Dec 4;11:1417076. doi: 10.3389/fnut.2024.1417076. PMID: 39698247; PMCID: PMC11652185. 12: Cui L, Li H, Shi W, Jing Y, Sun S, Ai S, Guo Z. The coordination effect of organic ligands in Ce-MOF brings about atomically dispersed Fe in CeO2 for TAC detection in commercial samples. Talanta. 2024 Dec 16;285:127405. doi: 10.1016/j.talanta.2024.127405. Epub ahead of print. PMID: 39689638. 13: Spiegel M. Fisetin as a Blueprint for Senotherapeutic Agents - Elucidating Geroprotective and Senolytic Properties with Molecular Modeling. Chemistry. 2024 Dec 17:e202403755. doi: 10.1002/chem.202403755. Epub ahead of print. PMID: 39688310. 14: Makhaeva GF, Grishchenko MV, Kovaleva NV, Boltneva NP, Rudakova EV, Astakhova TY, Timokhina EN, Pronkin PG, Lushchekina SV, Khudina OG, Zhilina EF, Shchegolkov EV, Lapshina MA, Dubrovskaya ES, Radchenko EV, Palyulin VA, Burgart YV, Saloutin VI, Charushin VN, Richardson RJ. Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease. Arch Pharm (Weinheim). 2025 Jan;358(1):e2400819. doi: 10.1002/ardp.202400819. PMID: 39686878; PMCID: PMC11650361. 15: Angeles Flores G, Cusumano G, Zengin G, Cetiz MV, Uba AI, Senkardes I, Koyuncu I, Yuksekdag O, Kalyniukova A, Emiliani C, Venanzoni R, Angelini P. Using In Vitro and In Silico Analysis to Investigate the Chemical Profile and Biological Properties of Polygonum istanbulicum Extracts. Plants (Basel). 2024 Dec 5;13(23):3421. doi: 10.3390/plants13233421. PMID: 39683214; PMCID: PMC11644544. 16: Kelebek H, Carikcioglu M, Kadiroglu P, Ereli E, Uzlasir T, Selli S. Phenolic Characterization and Quality Evaluation of Herbal Coffee from Roasted Juniper Berry Fruits (Juniperus drupacea L.): Elucidating the Impact of Roasting. Foods. 2024 Dec 6;13(23):3946. doi: 10.3390/foods13233946. PMID: 39683018; PMCID: PMC11641261. 17: Coyago-Cruz E, Barrigas A, Guachamin A, Heredia-Moya J, Zuñiga-Miranda J, Vera E. Bioactive Composition of Tropical Flowers and Their Antioxidant and Antimicrobial Properties. Foods. 2024 Nov 24;13(23):3766. doi: 10.3390/foods13233766. PMID: 39682838; PMCID: PMC11639929. 18: Thuy PT, Ha NX. Theoretical studies on the antioxidant activity of potential marine xanthones. Free Radic Res. 2024 Dec 15:1-15. doi: 10.1080/10715762.2024.2438918. Epub ahead of print. PMID: 39676294. 19: Ardoin R, Chaffee O, Lea J, Sookraj A, Boue S, Smith B, Dupre R, Olson DW, Broussard W, Priddy D. Ricemilks made from pigmented and aromatic rice varieties: Sensory analysis and physiochemical properties. J Food Sci. 2024 Dec;89(12):8770-8783. doi: 10.1111/1750-3841.17592. Epub 2024 Dec 14. PMID: 39674813. 20: Zhao J, Gao S, Zhou L, Rong K, Zuo F, Tang W, Zhu L. Trolox derivatives: Synthesis, structure-activity relationship and promote wound healing by regulating oxidative stress and inflammation. Bioorg Chem. 2024 Dec 7;154:108045. doi: 10.1016/j.bioorg.2024.108045. Epub ahead of print. PMID: 39672078.