Hexamethonium chloride | CAS# 60-25-3 (Cl) | Nicotinic receptor blocker

MedKoo Cat#: 463957 | Name: Hexamethonium chloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hexamethonium chloride is a nicotinic receptor antagonist that acts as a ganglionic blocker, primarily affecting the autonomic nervous system. It blocks transmission at both sympathetic and parasympathetic ganglia by inhibiting acetylcholine binding to nicotinic receptors, leading to decreased autonomic outflow. Historically used as an antihypertensive agent, hexamethonium is now mostly of research interest due to its broad systemic effects and limited therapeutic specificity.

Chemical Structure

Hexamethonium chloride

CAS#60-25-3 (chloride)

Theoretical Analysis

MedKoo Cat#: 463957

Name: Hexamethonium chloride

CAS#: 60-25-3 (chloride)

Chemical Formula: C12H30Cl2N2

Exact Mass: 0.0000

Molecular Weight: 273.29

Elemental Analysis: C, 52.74; H, 11.07; Cl, 25.94; N, 10.25

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 650.00	2 Weeks

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Related CAS #

60-26-4 (cation) 55-97-0 (bromide) 5187-74-6 (bromide dihydrate) 60-25-3 (chloride) 16986-49-5 (chloride dihydrate) 815-76-9 (monotartrate) 2079-78-9 (tartrate)

Synonym

Hexamethonium chloride; Hexamethonium dichloride; Esomid chloride; Hexon chloride; Hexone chloride; Hiohex chloride; Methium chloride; NSC 21643; NSC-21643; NSC21643;

IUPAC/Chemical Name

N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium chloride

InChi Key

PYIHTIJNCRKDBV-UHFFFAOYSA-L

InChi Code

InChI=1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

SMILES Code

C[N+](C)(CCCCCC[N+](C)(C)C)C.[Cl-].[Cl-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 273.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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