Synonym
BDP-13176; BDP 13176; BDP13176;
IUPAC/Chemical Name
5-[(3,4-dichlorophenyl)methyl]-4-oxo-1-piperidin-4-yl-N-pyridin-4-ylpyrazolo[4,3-c]pyridine-7-carboxamide
InChi Key
BMOUOZDRMBLNSI-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H22Cl2N6O2/c25-20-2-1-15(11-21(20)26)13-31-14-19(23(33)30-16-3-7-27-8-4-16)22-18(24(31)34)12-29-32(22)17-5-9-28-10-6-17/h1-4,7-8,11-12,14,17,28H,5-6,9-10,13H2,(H,27,30,33)
SMILES Code
O=C(C1=CN(CC2=CC=C(Cl)C(Cl)=C2)C(C3=C1N(C4CCNCC4)N=C3)=O)NC5=CC=NC=C5
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Fascin 1 (fascin) is an actin-bundling protein. It cross-links filamentous actin (F-actin) into tightly packed parallel bundles driving the formation of various cell surface protrusions, such as filopodia and invadopodia. They promote cell migration and invasion. Fascin 1 is either absent or shows low expression in normal epithelial tissues but shows overexpression in a number of cancers, with expression levels correlating with overall cancer aggressiveness and predicting poor clinical outcome. In a word, fascin is an actin-binding and bundling protein. It is not expressed in normal epithelial tissues but overexpressed in a variety of invasive epithelial tumors. It has a critical role in cancer cell metastasis by promoting cell migration and invasion.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
497.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chen K, Tao H, Zhu P, Chu M, Li X, Shi Y, Zhang L, Xu Y, Lv S, Huang L, Huang
W, Geng D. ADAM8 silencing suppresses the migration and invasion of fibroblast-
like synoviocytes via FSCN1/MAPK cascade in osteoarthritis. Arthritis Res Ther.
2024 Jan 13;26(1):20. doi: 10.1186/s13075-023-03238-w. PMID: 38218854; PMCID:
PMC10787439.
2: Zeyn Y, Harms G, Tubbe I, Montermann E, Röhrig N, Hartmann M, Grabbe S, Bros
M. Inhibitors of the Actin-Bundling Protein Fascin-1 Developed for Tumor Therapy
Attenuate the T-Cell Stimulatory Properties of Dendritic Cells. Cancers (Basel).
2022 May 31;14(11):2738. doi: 10.3390/cancers14112738. PMID: 35681718; PMCID:
PMC9179534.
