NS11757 | CAS#NA |SK channel inhibitor

MedKoo Cat#: 532363 | Name: NS11757

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NS11757 is a SK channel inhibitor with a K(d) value of 9 nM.

Chemical Structure

NS11757

CAS#NA

Theoretical Analysis

MedKoo Cat#: 532363

Name: NS11757

CAS#: NA

Chemical Formula: C17H15Cl2N3

Exact Mass: 331.0643

Molecular Weight: 332.22

Elemental Analysis: C, 61.46; H, 4.55; Cl, 21.34; N, 12.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NS11757; NS 11757; NS-11757.

IUPAC/Chemical Name

N-(6,7-dichloro-1,2,3,4-tetrahydronaphthalen-1-yl)-1H-1,3-benzodiazol-2-amine

InChi Key

JHLGZRSIUIFADK-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H15Cl2N3/c18-12-8-10-4-3-7-14(11(10)9-13(12)19)20-17-21-15-5-1-2-6-16(15)22-17/h1-2,5-6,8-9,14H,3-4,7H2,(H2,20,21,22)

SMILES Code

ClC1=CC2=C(C=C1Cl)CCCC2NC3=NC4=CC=CC=C4N3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 332.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sørensen US, Strøbaek D, Christophersen P, Hougaard C, Jensen ML, Nielsen EØ, Peters D, Teuber L. Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem. 2008 Dec 11;51(23):7625-34. doi: 10.1021/jm800809f. PubMed PMID: 18998663.