Dexamethasone sodium succinate | CAS# 3800-84-8 (sodium succinate)

MedKoo Cat#: 413597 | Name: Dexamethasone sodium succinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regulation of nuclear factor-κB activity and an activation of caspase-9 through second mitochondria-derived activator of caspase (Smac; an apoptosis promoting factor) release. Prolonged exposure was required to achieve maximum levels of apoptotic markers along with increased caspase-3 activation and DNA fragmentation. Dexamethasone also down-regulated anti apoptotic genes and increased IκB-alpha protein levels. Dexamethasone apoptotic activity is enhanced by the combination with thalidomide or its analogues and with proteasome inhibitor (e.g. bortezomib).

Chemical Structure

Dexamethasone sodium succinate

CAS#3800-84-8 (sodium succinate)

Theoretical Analysis

MedKoo Cat#: 413597

Name: Dexamethasone sodium succinate

CAS#: 3800-84-8 (sodium succinate)

Chemical Formula: C26H32FNaO8

Exact Mass: 0.0000

Molecular Weight: 514.52

Elemental Analysis: C, 60.69; H, 6.27; F, 3.69; Na, 4.47; O, 24.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

3936-02-5 (metasulfobenzoate sodium) 3800-84-8 (sodium succinate) 50-02-2 (free base) 1177-87-3 (acetate) 150587-07-8 (beloxil) 2265-64-7 (isonicotinate) 14899-36-6 (palmitate) 312-93-6 (phosphate) 2392-39-4 (phosphate sodium)

Synonym

Dexamethasone sodium succinate; NEOFORDEX®

IUPAC/Chemical Name

Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-9-fluoro-11,17-dihydroxy-16-methyl-, monosodium salt, (11beta,16alpha)-

InChi Key

VEMKNVZPCCPUIL-NJVDTJLMSA-M

InChi Code

InChI=1S/C26H33FO8.Na/c1-14-10-18-17-5-4-15-11-16(28)8-9-23(15,2)25(17,27)19(29)12-24(18,3)26(14,34)20(30)13-35-22(33)7-6-21(31)32;/h8-9,11,14,17-19,29,34H,4-7,10,12-13H2,1-3H3,(H,31,32);/q;+1/p-1/t14-,17+,18+,19+,23+,24+,25+,26+;/m1./s1

SMILES Code

C[C@@]12[C@](C(COC(CCC([O-])=O)=O)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 514.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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