MedKoo Cat#: 576219 | Name: Dexamethasone isonicotinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexamethasone isonicotinate is steroid with anti-inflammatory and immunosuppressant effects. It is used for the treatment of many conditions including: rheumatologic problems, a number of skin diseases such as erythema multiforme, severe allergies, asthma, chronic obstructive lung disease, croup, and cerebral edema, in addition to other medications in tuberculosis and a number of other infectious diseases.

Chemical Structure

Dexamethasone isonicotinate
Dexamethasone isonicotinate
CAS#2265-64-7 (isonicotinate)

Theoretical Analysis

MedKoo Cat#: 576219

Name: Dexamethasone isonicotinate

CAS#: 2265-64-7 (isonicotinate)

Chemical Formula: C28H32FNO6

Exact Mass: 497.2214

Molecular Weight: 497.56

Elemental Analysis: C, 67.59; H, 6.48; F, 3.82; N, 2.82; O, 19.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Auxiloson; Auxilsone; Dexamethasone 21-isonicotinate; Dexamethasone isonicotinate; HE111; HE-111; HE 111; Voren
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((4-pyridinylcarbonyl)oxy)-, (11beta,16alpha)-
InChi Key
BQTXJHAJMDGOFI-NJLPOHDGSA-N
InChi Code
InChI=1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1
SMILES Code
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)c5ccncc5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 497.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Warris LT, van den Heuvel-Eibrink MM, den Hoed MA, Aarsen FK, Pieters R, van den Akker EL. Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review. Pediatr Blood Cancer. 2014 Jul;61(7):1313-8. doi: 10.1002/pbc.24988. Epub 2014 Feb 16. Review. PubMed PMID: 24532490. 2: Keeney GE, Gray MP, Morrison AK, Levas MN, Kessler EA, Hill GD, Gorelick MH, Jackson JL. Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Pediatrics. 2014 Mar;133(3):493-9. doi: 10.1542/peds.2013-2273. Epub 2014 Feb 10. Review. PubMed PMID: 24515516; PubMed Central PMCID: PMC3934336. 3: Choi S, Rodseth R, McCartney CJ. Effects of dexamethasone as a local anaesthetic adjuvant for brachial plexus block: a systematic review and meta-analysis of randomized trials. Br J Anaesth. 2014 Mar;112(3):427-39. doi: 10.1093/bja/aet417. Epub 2014 Jan 10. Review. PubMed PMID: 24413428. 4: Urbańska J, Karewicz A, Nowakowska M. Polymeric delivery systems for dexamethasone. Life Sci. 2014 Feb 6;96(1-2):1-6. doi: 10.1016/j.lfs.2013.12.020. Epub 2013 Dec 25. Review. PubMed PMID: 24373835. 5: Redman E, Powell C. Question 1: Prednisolone or dexamethasone for acute exacerbations of asthma: do they have similar efficacy in the management of exacerbations of childhood asthma? Arch Dis Child. 2013 Nov;98(11):916-9. doi: 10.1136/archdischild-2013-304937. Review. PubMed PMID: 24123403.