Dexamethasone phosphate | CAS# 312-93-6 (phosphate) | adrenal corticosteroid

MedKoo Cat#: 330108 | Name: Dexamethasone phosphate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexamethasone phosphate is a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors.

Chemical Structure

Dexamethasone phosphate

CAS#312-93-6 (phosphate)

Theoretical Analysis

MedKoo Cat#: 330108

Name: Dexamethasone phosphate

CAS#: 312-93-6 (phosphate)

Chemical Formula: C22H30FO8P

Exact Mass: 472.1662

Molecular Weight: 472.45

Elemental Analysis: C, 55.93; H, 6.40; F, 4.02; O, 27.09; P, 6.56

Price and Availability

Size	Price	Availability	Quantity
500mg	USD 650.00	2 weeks

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Related CAS #

3936-02-5 (metasulfobenzoate sodium) 3800-84-8 (sodium succinate) 50-02-2 (free base) 1177-87-3 (acetate) 150587-07-8 (beloxil) 2265-64-7 (isonicotinate) 14899-36-6 (palmitate) 312-93-6 (phosphate) 2392-39-4 (phosphate sodium)

Synonym

EGP-437; EGP 437; EGP437; Dexamethasone phosphate; Hexadrol phosphate; Neodecadron; Oradexon phosphate; Wymesone; Betnelan phosphate; Dexamethasone 21-phosphate;

IUPAC/Chemical Name

2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl dihydrogen phosphate

InChi Key

VQODGRNSFPNSQE-CXSFZGCWSA-N

InChi Code

InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

SMILES Code

C[C@@]12[C@](C(COP(O)(O)=O)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O

Appearance

Solid powder

Purity

>90% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 472.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sinner B. Perioperatives Dexamethason [Perioperative dexamethasone]. Anaesthesist. 2019 Oct;68(10):676-682. German. doi: 10.1007/s00101-019-00672-x. PMID: 31595319. 2: Giles AJ, Hutchinson MND, Sonnemann HM, Jung J, Fecci PE, Ratnam NM, Zhang W, Song H, Bailey R, Davis D, Reid CM, Park DM, Gilbert MR. Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy. J Immunother Cancer. 2018 Jun 11;6(1):51. doi: 10.1186/s40425-018-0371-5. PMID: 29891009; PMCID: PMC5996496. 3: Madamsetty VS, Mohammadinejad R, Uzieliene I, Nabavi N, Dehshahri A, García- Couce J, Tavakol S, Moghassemi S, Dadashzadeh A, Makvandi P, Pardakhty A, Aghaei Afshar A, Seyfoddin A. Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems. ACS Biomater Sci Eng. 2022 May 9;8(5):1763-1790. doi: 10.1021/acsbiomaterials.2c00026. Epub 2022 Apr 19. PMID: 35439408. 4: Black R, Grodzinsky AJ. Dexamethasone: chondroprotective corticosteroid or catabolic killer? Eur Cell Mater. 2019 Nov 22;38:246-263. doi: 10.22203/eCM.v038a17. PMID: 31755076; PMCID: PMC7211090. 5: Moore SG. Intravenous Dexamethasone as an Analgesic: A Literature Review. AANA J. 2018 Dec;86(6):488-493. PMID: 31584423. 6: Li AFY, Wang CL, Tai HY, Fu YJ, Tsai FT, Tsai YC, Ko YL, Li MJ, Lin CC, Chang TJ. Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application. J Chin Med Assoc. 2021 Mar 1;84(3):245-247. doi: 10.1097/JCMA.0000000000000485. PMID: 33433137. 7: Upadhyayula PS, Higgins DM, Argenziano MG, Spinazzi EF, Wu CC, Canoll P, Bruce JN. The Sledgehammer in Precision Medicine: Dexamethasone and Immunotherapeutic Treatment of Glioma. Cancer Invest. 2022 Jul;40(6):554-566. doi: 10.1080/07357907.2021.1944178. Epub 2022 Mar 24. PMID: 34151678. 8: Ho CM, Wu HL, Ho ST, Wang JJ. Dexamethasone prevents postoperative nausea and vomiting: benefit versus risk. Acta Anaesthesiol Taiwan. 2011 Sep;49(3):100-4. doi: 10.1016/j.aat.2011.06.002. PMID: 21982171. 9: Vohra M, Sharma AR, Satyamoorthy K, Rai PS. Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infection. Per Med. 2021 Jul;18(4):389-398. doi: 10.2217/pme-2020-0183. Epub 2021 Jun 4. PMID: 34086487; PMCID: PMC8186476. 10: McIntyre P. Should dexamethasone be part of routine therapy of bacterial meningitis in industrialised countries? Adv Exp Med Biol. 2005;568:189-97. doi: 10.1007/0-387-25342-4_13. PMID: 16107073. 11: Gaignage P, Lognay G, Bosson D, Vertongen D, Dreze P, Marlier M, Severin M. Dexamethasone bovine pharmacokinetics. Eur J Drug Metab Pharmacokinet. 1991 Jul- Sep;16(3):219-21. doi: 10.1007/BF03189963. PMID: 1814739. 12: Weber C, Liegl R. Dexamethason-Stäbchen im Bereich der Makula nach vitreoretinaler Chirurgie [Dexamethasone remnant on the macula after vitreoretinal surgery]. Ophthalmologie. 2023 May;120(5):459. German. doi: 10.1007/s00347-022-01790-5. Epub 2023 Jan 19. PMID: 36656386. 13: Buxton JD. Dexamethasone sodium phosphate. Br Dent J. 1981 Nov 3;151(9):283. doi: 10.1038/sj.bdj.4804687. PMID: 6945115. 14: Batistaki C, Kaminiotis E, Papadimos T, Kostopanagiotou G. A Narrative Review of the Evidence on the Efficacy of Dexamethasone on Postoperative Analgesic Consumption. Clin J Pain. 2017 Nov;33(11):1037-1046. doi: 10.1097/AJP.0000000000000486. PMID: 28177939. 15: Schreiber N, Gebauer D, Schittek G, Sandner-Kiesling A. Dexamethason für die postoperative Schmerztherapie in der Bandscheibenchirurgie [Role of Dexamethasone for Pain Management in Intervertebral Disc Surgery]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2022 Feb;57(2):138-141. German. doi: 10.1055/a-1483-9092. Epub 2022 Feb 16. PMID: 35172344. 16: Tun SBB, Chua M, Tan GSW, Leibiger I, Ali Y, Barathi VA, Berggren PO. Local Dexamethasone Administration Delays Allogeneic Islet Graft Rejection in the Anterior Chamber of the Eye of Non-Human Primates. Cell Transplant. 2022 Jan- Dec;31:9636897221098038. doi: 10.1177/09636897221098038. PMID: 35603580; PMCID: PMC9125106. 17: Finch ER, Janke LJ, Li L, Payton MA, Jenkins DA, Crews KR, Relling MV, Karol SE. Dasatinib does not exacerbate dexamethasone-induced osteonecrosis in murine models of acute lymphoblastic leukemia therapy. Pediatr Blood Cancer. 2022 Apr;69(4):e29490. doi: 10.1002/pbc.29490. Epub 2021 Dec 5. PMID: 34866312; PMCID: PMC8860849. 18: Allan SG, Leonard RC. Dexamethasone antiemesis and side-effects. Lancet. 1986 May 3;1(8488):1035. doi: 10.1016/s0140-6736(86)91305-x. PMID: 2871314. 19: Kumar P, Mahajan G. Dexamethasone for management of neonatal meningitis. Indian J Pediatr. 2013 Feb;80(2):155-6. doi: 10.1007/s12098-013-0975-1. Epub 2013 Jan 26. PMID: 23355014. 20: Bian X, Liu H, Sun J, Zhang X, Li N, Chen M. Efficacy of Dexamethasone for Reducing Edema and Ecchymosis After Rhinoplasty: A Systematic Review and Meta- analysis. Aesthetic Plast Surg. 2020 Oct;44(5):1672-1684. doi: 10.1007/s00266-020-01743-w. Epub 2020 May 7. PMID: 32383002.

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