Synonym
Dexamethasone cipecilate; NS-126; NS 126; NS126.
IUPAC/Chemical Name
2-((8S,9R,10S,11S,13S,14S,16R,17R)-17-((cyclopropanecarbonyl)oxy)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl cyclohexanecarboxylate
InChi Key
JPTKVJWWVFLEJL-GVPGRCOTSA-N
InChi Code
InChI=1S/C33H43FO7/c1-19-15-25-24-12-11-22-16-23(35)13-14-30(22,2)32(24,34)26(36)17-31(25,3)33(19,41-29(39)21-9-10-21)27(37)18-40-28(38)20-7-5-4-6-8-20/h13-14,16,19-21,24-26,36H,4-12,15,17-18H2,1-3H3/t19-,24+,25+,26+,30+,31+,32+,33+/m1/s1
SMILES Code
O=C(C1CCCCC1)OCC([C@@]2(OC(C3CC3)=O)[C@H](C)C[C@@]4([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@]24C)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
570.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sasagawa T, Yamada T, Nakagawa T, Tsujioka T, Takahashi Y, Kawakita N, Nonaka K, Nakamura A. In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84. doi: 10.3109/00498254.2011.582894. Epub 2011 Jun 10. PubMed PMID: 21657966.
2: Yu SQ, Wang DH. Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord. Acta Pharmacol Sin. 2011 Jun;32(6):845-52. doi: 10.1038/aps.2011.43. PubMed PMID: 21642952; PubMed Central PMCID: PMC4009958.
3: Gotoh M, Okubo K, Okuda M, Hamada C. Clinical pharmacology study of the corticosteroid nasal spray dexamethasone cipecilate (NS-126): examination of the durability of efficacy in the nasal induction test. Expert Opin Investig Drugs. 2010 Dec;19(12):1475-86. doi: 10.1517/13543784.2010.531258. Epub 2010 Nov 11. PubMed PMID: 21067470.
4: Inoue N, Hashino A, Kageyama K, Zhang X, Sasagawa T, Kawakita N, Takahashi Y, Yoshida K, Hashimoto M, Mori K, Kyoi T. Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis. J Pharmacol Sci. 2010;112(1):73-82. Epub 2010 Jan 6. PubMed PMID: 20051657.
5: Pech V, Sikka SC, Sindhu RK, Vaziri ND, Majid DS. Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets. Am J Hypertens. 2006 May;19(5):534-40. PubMed PMID: 16647629.
6: Etaugh C, Kelliher R, Osborne B, Rose M. The role of visual and haptic cues in children's discrimination learning. J Genet Psychol. 1981 Mar;138(1st Half):75-9. PubMed PMID: 7217924.
