Synonym
Succinylcholine iodide; NSC221197; NSC-221197; NSC 221197; Succinylcholine diiodide
IUPAC/Chemical Name
Ethanaminium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl-, diiodide (9CI)
InChi Key
QMJHHGXCWYZSBV-UHFFFAOYSA-L
InChi Code
InChI=1S/C14H30N2O4.2HI/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
SMILES Code
O=C(OCC[N+](C)(C)C)CCC(OCC[N+](C)(C)C)=O.[I-].[I-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
544.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sparr HJ, Jöhr M. Succinylcholin-Update [Succinylcholine--update]. Anaesthesist. 2002 Jul;51(7):565-75. German. doi: 10.1007/s00101-002-0324-7. PMID: 12243044.
2: THESLEFF S, DARDEL OV, HOLMBERG G. Succinylcholine iodide; a new muscular relaxant. Br J Anaesth. 1952 Oct;24(4):238-44. doi: 10.1093/bja/24.4.238. PMID: 12987537.
3: Miller R. Will succinylcholine ever disappear? Anesth Analg. 2004 Jun;98(6):1674-5. doi: 10.1213/01.ane.0000126935.87196.4c. PMID: 15155326.
4: Poulsen H, Hougs W. The effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39. Acta Anaesthesiol Scand. 2007 Sep;51(8):1018-42; discussion 1043. doi: 10.1111/j.1399-6576.2007.01399.x. PMID: 17697296.
5: Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI. Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 2006 Apr;104(4):724-33. doi: 10.1097/00000542-200604000-00017. PMID: 16571968.
6: Geyer BC, Larrimore KE, Kilbourne J, Kannan L, Mor TS. Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. PLoS One. 2013;8(3):e59159. doi: 10.1371/journal.pone.0059159. Epub 2013 Mar 11. PMID: 23536865; PMCID: PMC3594170.
7: Suparschi V, Sigaut S, Paugam-Burtz C. Prolonged muscle relaxation following succinylcholine administration in a cirrhotic patient: A case report. Eur J Anaesthesiol. 2019 Nov;36(11):883-884. doi: 10.1097/EJA.0000000000001057. PMID: 31580290.
8: Lee C. Goodbye suxamethonium! Anaesthesia. 2009 Mar;64 Suppl 1:73-81. doi: 10.1111/j.1365-2044.2008.05873.x. PMID: 19222434.
9: Dexter F, Gan TJ, Naguib M, Lubarsky DA. Cost identification analysis for succinylcholine. Anesth Analg. 2001 Mar;92(3):693-9. doi: 10.1097/00000539-200103000-00028. PMID: 11226104.
10: Warner DO. Intramuscular succinylcholine and laryngospasm. Anesthesiology. 2001 Oct;95(4):1039-40. doi: 10.1097/00000542-200110000-00044. PMID: 11605908.
