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MedKoo Cat#: 592228 | Name: Succinylcholine chloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Succinylcholine chloride is a quaternary skeletal muscle relaxant. It is a depolarizing relaxant, acting in about 30 seconds with an average duration of three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.

Chemical Structure

Succinylcholine chloride
Succinylcholine chloride
CAS#71-27-2 (chloride)

Theoretical Analysis

MedKoo Cat#: 592228

Name: Succinylcholine chloride

CAS#: 71-27-2 (chloride)

Chemical Formula: C14H30Cl2N2O4

Exact Mass: 0.0000

Molecular Weight: 361.30

Elemental Analysis: C, 46.54; H, 8.37; Cl, 19.62; N, 7.75; O, 17.71

Price and Availability

Size Price Availability Quantity
1g USD 150.00 2 weeks
5g USD 350.00 2 weeks
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Related CAS #
306-40-1 (free base) 541-19-5 (iodide) 71-27-2 (chloride)
Synonym
AI3-51679, Anectine, Anectine chloride, Choline chloride succinate (2:1), Choline succinate dichloride, Lysthenon, Lysthenone, Midarine, Myoplegine, Succinylcholine chloride; NSC 49132; NSC-49132; NSC49132, Pantolax, Quelicin, Quelicin chloride, Scoline, Scoline chloride, Succin, Succinyl bischoline chloride, Succinyl-asta, Succinylbischoline dichloride, Succinylcholine dichloride, Succinyldicholine chloride, Succinylforte, Sucostrin, Sucostrin chloride, Sukolin, Suxamethionium chloride, Suxamethonium chloride, Suxamethonium dichloride
IUPAC/Chemical Name
2,2'-(succinylbis(oxy))bis(N,N,N-trimethylethan-1-aminium) chloride
InChi Key
YOEWQQVKRJEPAE-UHFFFAOYSA-L
InChi Code
InChI=1S/C14H30N2O4.2ClH/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
SMILES Code
O=C(OCC[N+](C)(C)C)CCC(OCC[N+](C)(C)C)=O.[Cl-].[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Succinylcholine is a skeletal muscle relaxant.
In vitro activity:
Results showed a progressive increase in muscle cells' sensitivity to succinylcholine chloride post-denervation, without significant association with γ-AChR expression. Reference: Mol Med Rep. 2015 Nov;12(5):7796-800. https://pubmed.ncbi.nlm.nih.gov/26458413/
In vivo activity:
Succinylcholine chloride may cause life-threatening hyperkalemia. A hospitalized patient with a severe course of COVID-19 underwent reintubation on day 16. The applied scheme was rapid sequence induction and intubation with administration of Succinylcholine chloride. Immediately after intubation, there was a sudden cardiac arrest due to hyperkalemia (cK + 10.2 meq/L). Reference: Front Med (Lausanne). 2022 May 11;9:843282. https://pubmed.ncbi.nlm.nih.gov/35646979/

Preparing Stock Solutions

The following data is based on the product molecular weight 361.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wang H, Fu W, Liu G, Li ST. Effects of skeletal muscle denervation on the potency of succinylcholine. Mol Med Rep. 2015 Nov;12(5):7796-800. doi: 10.3892/mmr.2015.4392. Epub 2015 Sep 30. PMID: 26458413. 2. Putowski M, Drygalski T, Morajda A, Woroń J, Sanak T, Wordliczek J. Sudden Cardiac Arrest in a Patient With COVID-19 as a Result of Severe Hyperkalemia After Administration of Succinylcholine Chloride for Reintubation. A Case Report. Front Med (Lausanne). 2022 May 11;9:843282. doi: 10.3389/fmed.2022.843282. PMID: 35646979; PMCID: PMC9130649. 3. Lin D, He Y, Dong R, Li W, Meng F, Zhang Y, Yang L. The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Dec 15;263:120172. doi: 10.1016/j.saa.2021.120172. Epub 2021 Jul 10. PMID: 34273893.
In vitro protocol:
1. Wang H, Fu W, Liu G, Li ST. Effects of skeletal muscle denervation on the potency of succinylcholine. Mol Med Rep. 2015 Nov;12(5):7796-800. doi: 10.3892/mmr.2015.4392. Epub 2015 Sep 30. PMID: 26458413.
In vivo protocol:
1. Putowski M, Drygalski T, Morajda A, Woroń J, Sanak T, Wordliczek J. Sudden Cardiac Arrest in a Patient With COVID-19 as a Result of Severe Hyperkalemia After Administration of Succinylcholine Chloride for Reintubation. A Case Report. Front Med (Lausanne). 2022 May 11;9:843282. doi: 10.3389/fmed.2022.843282. PMID: 35646979; PMCID: PMC9130649. 2. Lin D, He Y, Dong R, Li W, Meng F, Zhang Y, Yang L. The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Dec 15;263:120172. doi: 10.1016/j.saa.2021.120172. Epub 2021 Jul 10. PMID: 34273893.
1: Boleyn J, McLaury M, Wieman S. Suspected Pseudocholinesterase Deficiency During Left Thyroid Lobectomy and Isthmusectomy: A Case Report. S D Med. 2024 Jun;77(6):266-269. PMID: 39013099. 2: Hager HH, Burns B. Succinylcholine Chloride. 2023 Feb 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29763160. 3: Putowski M, Drygalski T, Morajda A, Woroń J, Sanak T, Wordliczek J. Sudden Cardiac Arrest in a Patient With COVID-19 as a Result of Severe Hyperkalemia After Administration of Succinylcholine Chloride for Reintubation. A Case Report. Front Med (Lausanne). 2022 May 11;9:843282. doi: 10.3389/fmed.2022.843282. PMID: 35646979; PMCID: PMC9130649. 4: Lin D, He Y, Dong R, Li W, Meng F, Zhang Y, Yang L. The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Dec 15;263:120172. doi: 10.1016/j.saa.2021.120172. Epub 2021 Jul 10. PMID: 34273893. 5: Park CO, Ro H, Lee J. Effects of intubation with a double-lumen endotracheal tube on intraocular pressure during rapid sequence induction using succinylcholine chloride in patients with or without underlying systemic hypertension. Anesth Pain Med (Seoul). 2019 Oct 31;14(4):449-455. doi: 10.17085/apm.2019.14.4.449. PMID: 33329776; PMCID: PMC7713805. 6: Szterk A, Zmysłowski A, Gorinstein S. Application of hydrophilic interaction liquid chromatography for the quantification of succinylcholine in Active Pharmaceutical Ingredient and medicinal product. Identification of new impurities of succinylcholine chloride. Heliyon. 2018 Dec 28;4(12):e01097. doi: 10.1016/j.heliyon.2018.e01097. PMID: 30627678; PMCID: PMC6312872. 7: Pan Q, He Z, Xia D, Gu X, Wang H, Sun J. Fluorescent Determination of Succinylcholine Chloride by Naphthalimide/ Stilbazolium Dye ⊂ CP5A. J Fluoresc. 2018 Mar;28(2):581-587. doi: 10.1007/s10895-018-2219-2. Epub 2018 Apr 23. PMID: 29687368. 8: Ayad MM, Belal F, Hosney MM, Abo El Abass S, Elsayed N. Spectroscopic determination of succinylcholine in dosage forms using eosin Y. Luminescence. 2018 Mar;33(2):376-381. doi: 10.1002/bio.3424. Epub 2017 Nov 8. PMID: 29115039. 9: Liao AH, Lin YC, Bai CH, Chen CY. Optimal dose of succinylcholine for laryngeal mask airway insertion: systematic review, meta-analysis and metaregression of randomised control trials. BMJ Open. 2017 Aug 4;7(8):e014274. doi: 10.1136/bmjopen-2016-014274. PMID: 28780538; PMCID: PMC5724107. 10: Revenko SV, Selector LY, Gavrilov IY, Nesterov AV, Limonov EV, Mudraya IS, Kirpatovskii VI. Electrical Rhythms Revealed by Harmonic Analysis of a High- Resolution Cardiogram. Bull Exp Biol Med. 2015 May;159(1):11-5. doi: 10.1007/s10517-015-2877-x. Epub 2015 Jun 2. PMID: 26033579. 11: De Winter S, Vanbrabant P, Vi NT, Deng X, Spriet I, Van Schepdael A, Gillet JB. Impact of temperature exposure on stability of drugs in a real-world out-of- hospital setting. Ann Emerg Med. 2013 Oct;62(4):380-387.e1. doi: 10.1016/j.annemergmed.2013.04.018. Epub 2013 May 24. PMID: 23711878. 12: Boulay D, Antier D, Laffon M. Stability and sterility of succinylcholine chloride. Int J Obstet Anesth. 2010 Jul;19(3):349-50. doi: 10.1016/j.ijoa.2010.03.012. Epub 2010 Jun 3. PMID: 20605433. 13: Matsumoto N, Tomioka A, Sato T, Kawasaki M, Kadoi Y, Saito S. Relationship between cardiac output and onset of succinylcholine chloride action in electroconvulsive therapy patients. J ECT. 2009 Dec;25(4):246-9. doi: 10.1097/YCT.0b013e3181926ac0. PMID: 19252443. 14: Trusley C, Ben M, Kupiec TC, Trissel LA. Compatibility and stability of palonosetron hydrochloride with four neruomuscular blocking agents during simulated y-site administration. Int J Pharm Compd. 2008 Mar-Apr;12(2):156-60. PMID: 23969608. 15: Adnet F, Le Moyec L, Smith CE, Galinski M, Jabre P, Lapostolle F. Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy. Emerg Med J. 2007 Mar;24(3):168-9. doi: 10.1136/emj.2006.041053. PMID: 17351219; PMCID: PMC2660020. 16: Li LC, Parasrampuria J, Bommireddi A, Pec E, Dudleston A, Mayoral J. Moist- heat sterilization and the chemical stability of heat-labile parenteral solutions. Drug Dev Ind Pharm. 1998 Jan;24(1):89-93. doi: 10.3109/03639049809082357. PMID: 15605602. 17: Nishihara F, Saito S. Adjustment of anaesthesia depth using bispectral index prolongs seizure duration in electroconvulsive therapy. Anaesth Intensive Care. 2004 Oct;32(5):661-5. doi: 10.1177/0310057X0403200509. PMID: 15535490. 18: Patterson BM, Danielson ND, Sommer AJ. Attenuated total internal reflectance infrared microspectroscopy as a detection technique for capillary electrophoresis. Anal Chem. 2004 Jul 1;76(13):3826-32. doi: 10.1021/ac0400111. PMID: 15228361. 19: Patterson BM, Danielson ND, Sommer AJ. Attenuated total internal reflectance infrared microspectroscopy as a detection technique for high-performance liquid chromatography. Anal Chem. 2003 Mar 15;75(6):1418-24. doi: 10.1021/ac0205917. PMID: 12659204. 20: Cope TM, Hunter JM. Selecting neuromuscular-blocking drugs for elderly patients. Drugs Aging. 2003;20(2):125-40. doi: 10.2165/00002512-200320020-00004. PMID: 12534313.