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MedKoo Cat#: 414886 | Name: D –α-Tocopherol  PEG 1000 succinate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

D –α-Tocopherol PEG 1000 succinate is a non-ionic surfactant, which is useful in drug formation, , DNA & RNA delivery. It is bioactive in many aspects: it inhibits P-glycoprotein (P-gp) and can reverse multidrug resistant (MDR). It also promotes penetration of. It induces apoptosis via mitochondrial-associated apoptotic pathways, it also inhibits metastasis.

Chemical Structure

D –α-Tocopherol  PEG 1000 succinate
D –α-Tocopherol  PEG 1000 succinate
CAS#9002-96-4 (PEG 1000 succinate)

Theoretical Analysis

MedKoo Cat#: 414886

Name: D –α-Tocopherol  PEG 1000 succinate

CAS#: 9002-96-4 (PEG 1000 succinate)

Chemical Formula: C35H58O6

Exact Mass: 574.4233

Molecular Weight: 574.84

Elemental Analysis: C, 73.13; H, 10.17; O, 16.70

Price and Availability

Size Price Availability Quantity
5g USD 285.00 2 Weeks
25g USD 850.00 2 Weeks
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Related CAS #
59-02-9 (vitamin E) 58-95-7 (acetate) 17407-37-3 (Hemisuccinate) 4345-03-3(succinate) 9002-96-4 (PEG 1000 succinate) 38976-17-9 (phosphate)
Synonym
D –α-Tocopherol  PEG 1000 succinate; D-α-Tocopherol polyethylene glycol succinate, TPGS, Vitamin E polyethylene glycol succinate, Vitamin E-TPGS
IUPAC/Chemical Name
D –α-Tocopherol PEG 1000 succinate; 2-hydroxyethyl (2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-yl) succinate
InChi Key
HNVHRJWUAMIIDU-UHFFFAOYSA-N
InChi Code
1S/C39H66O8/c1-28(2)12-9-13-29(3)14-10-15-30(4)16-11-20-39(8)21-19-34-33(7)37(31(5)32(6)38(34)47-39)46-36(42)18-17-35(41)45-27-26-44-25-24-43-23-22-40/h28-30,40H,9-27H2,1-8H3
SMILES Code
[H]OCCOC(CCC(OC1=C(C)C(C)=C(OC(C)(CCCC(C)CCCC(C)CCCC(C)C)CC2)C2=C1C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
[Guan, Y., Wang, Ly., Wang, B. et al. Recent Advances of D-α-tocopherol Polyethylene Glycol 1000 Succinate Based Stimuli-responsive Nanomedicine for Cancer Treatment. CURR MED SCI 40, 218–231 (2020). https://doi.org/10.1007/s11596-020-2185-1]

Preparing Stock Solutions

The following data is based on the product molecular weight 574.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tan X, Fang Y, Ren Y, Li Y, Wu P, Yang X, Liu W. D-α-tocopherol polyethylene glycol 1000 succinate-modified liposomes with an siRNA corona confer enhanced cellular uptake and targeted delivery of doxorubicin via tumor priming. Int J Nanomedicine. 2019 Feb 18;14:1255-1268. doi: 10.2147/IJN.S191858. PMID: 30863058; PMCID: PMC6391153. 2: Guan Y, Wang LY, Wang B, Ding MH, Bao YL, Tan SW. Recent Advances of D-α- tocopherol Polyethylene Glycol 1000 Succinate Based Stimuli-responsive Nanomedicine for Cancer Treatment. Curr Med Sci. 2020 Apr;40(2):218-231. doi: 10.1007/s11596-020-2185-1. Epub 2020 Apr 26. PMID: 32337683. 3: Metin E, Mutlu P, Gündüz U. Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles. Anticancer Agents Med Chem. 2018;18(8):1138-1147. doi: 10.2174/1871520618666180313154724. PMID: 29532763. 4: Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm Res. 2004 Feb;21(2):201-30. doi: 10.1023/b:pham.0000016235.32639.23. PMID: 15032302. 5: Baumgart BR, Van Vleet TR, Simic D, Salcedo TW, Lentz K, Donegan M, Davies MH, Bunch RT, Sanderson TP, Lange RW. D-α-tocopheryl polyethylene glycol 1000 succinate-containing vehicles provide no detectable chemoprotection from oxidative damage. J Appl Toxicol. 2015 Jul;35(7):791-8. doi: 10.1002/jat.3072. Epub 2014 Oct 28. PMID: 25348750. 6: Hadinoto K, Sundaresan A, Cheow WS. Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):427-43. doi: 10.1016/j.ejpb.2013.07.002. Epub 2013 Jul 17. PMID: 23872180. 7: Agrawal P, Sonali, Singh RP, Sharma G, Mehata AK, Singh S, Rajesh CV, Pandey BL, Koch B, Muthu MS. Bioadhesive micelles of d-α-tocopherol polyethylene glycol succinate 1000: Synergism of chitosan and transferrin in targeted drug delivery. Colloids Surf B Biointerfaces. 2017 Apr 1;152:277-288. doi: 10.1016/j.colsurfb.2017.01.021. Epub 2017 Jan 15. PMID: 28122295. 8: Aydemir O, Celebi S, Yilmaz T, Yekeler H, Kükner AS. Protective effects of vitamin E forms (alpha-tocopherol, gamma-tocopherol and d-alpha-tocopherol polyethylene glycol 1000 succinate) on retinal edema during ischemia-reperfusion injury in the guinea pig retina. Int Ophthalmol. 2004 Oct-Dec;25(5-6):283-9. doi: 10.1007/s10792-005-2034-z. Epub 2006 Mar 7. PMID: 16532291. 9: Gu SF, Wang LY, Tian YJ, Zhou ZX, Tang JB, Liu XR, Jiang HP, Shen YQ. Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-α-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine. J Zhejiang Univ Sci B. 2019 Mar.;20(3):273-281. doi: 10.1631/jzus.B1800346. PMID: 30829014; PMCID: PMC6421126. 10: Chamsai B, Limmatvapirat S, Sungthongjeen S, Sriamornsak P. Enhancement of solubility and oral bioavailability of manidipine by formation of ternary solid dispersion with d-α-tocopherol polyethylene glycol 1000 succinate and copovidone. Drug Dev Ind Pharm. 2017 Dec;43(12):2064-2075. doi: 10.1080/03639045.2017.1371731. Epub 2017 Sep 10. PMID: 28836855.