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MedKoo Cat#: 414883 | Name: D-α-Tocopherol 
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

D-α-Tocopherol is used in DNA and RNA delivery. It is a lipid antioxidant, usually added as a preservative to phospholipids tom slow down any oxidation reaction during liposome preparation. This product is from vegetable oil, Type V, ~1000 IU/g.

Chemical Structure

D-α-Tocopherol 
D-α-Tocopherol 
CAS#59-02-9 (vitamin E)

Theoretical Analysis

MedKoo Cat#: 414883

Name: D-α-Tocopherol 

CAS#: 59-02-9 (vitamin E)

Chemical Formula: C29H50O2

Exact Mass: 430.3811

Molecular Weight: 430.72

Elemental Analysis: C, 80.87; H, 11.70; O, 7.43

Price and Availability

Size Price Availability Quantity
1g USD 90.00 Ready to ship
5g USD 150.00 Ready to ship
10g USD 250.00 Ready to ship
25g USD 450.00 2 Weeks
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Related CAS #
59-02-9 (vitamin E) 58-95-7 (acetate) 17407-37-3 (Hemisuccinate) 4345-03-3(succinate) 9002-96-4 (PEG 1000 succinate) 38976-17-9 (phosphate)
Synonym
D-α-Tocopherol; Vitamin E; α-Tocopherol; alpha-Tocopherol; D-alpha-Tocopherol
IUPAC/Chemical Name
(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol
InChi Key
GVJHHUAWPYXKBD-IEOSBIPESA-N
InChi Code
InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
SMILES Code
CC1=C2C(O[C@@](C)(CC2)CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)=C(C(C)=C1O)C
Appearance
liquid
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#A24M11B19
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction
Biological target:
Human endogenous metabolite
In vitro activity:
Therefore, hydrophilic d-α-tocopherol polyethylene glycol succinate (TPGS) was copolymerised with PBAE to increase the biocompatibility and to decrease the potential cytotoxicity of the cationic polymer-DNA plasmid polyplex nanoparticles (NPs) formed through electrostatic forces between the polymer and DNA. Reference: Ding J, Zhang H, Dai T, Gao X, Yin Z, Wang Q, Long M, Tan S. TPGS-b-PBAE Copolymer-Based Polyplex Nanoparticles for Gene Delivery and Transfection In Vivo and In Vitro. Pharmaceutics. 2024 Jan 31;16(2):213. doi: 10.3390/pharmaceutics16020213. PMID: 38399267; PMCID: PMC10891721.
In vivo activity:
Serum glucose levels were reduced after 6 h, but the difference was not significant compared to subcutaneous insulin; at 12 h and 24 h, insulin levels were significantly higher in rats treated with NPs than in rats treated with subcutaneous insulin. There was no significant difference in serum insulin levels at 12 h and 24 h compared to non-diabetic rats. Reference: Abd-Alhussain GK, Alatrakji MQYM, Ahmed SJ, Fawzi HA. Efficacy of oral insulin nanoparticles for the management of hyperglycemia in a rat model of diabetes induced with streptozotocin. J Med Life. 2024 Feb;17(2):217-225. doi: 10.25122/jml-2023-0355. PMID: 38813352; PMCID: PMC11131628.
Solvent mg/mL mM
Solubility
DMSO 100.0 232.17
Ethanol 100.0 232.17
H2O 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 430.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
1: Ding J, Zhang H, Dai T, Gao X, Yin Z, Wang Q, Long M, Tan S. TPGS-b-PBAE Copolymer-Based Polyplex Nanoparticles for Gene Delivery and Transfection In Vivo and In Vitro. Pharmaceutics. 2024 Jan 31;16(2):213. doi: 10.3390/pharmaceutics16020213. PMID: 38399267; PMCID: PMC10891721. 2: Shah VM, Rizvi S, Smith A, Tsuda M, Krieger M, Pelz C, MacPherson K, Eng J, Chin K, Munks MW, Daniel CJ, Al-Fatease A, Yardimci GG, Langer EM, Brody JR, Sheppard BC, Alani AW, Sears RC. Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment. Pharmaceutics. 2023 Nov 21;15(12):2651. doi: 10.3390/pharmaceutics15122651. PMID: 38139993; PMCID: PMC10747591.
In vivo protocol:
1:Abd-Alhussain GK, Alatrakji MQYM, Ahmed SJ, Fawzi HA. Efficacy of oral insulin nanoparticles for the management of hyperglycemia in a rat model of diabetes induced with streptozotocin. J Med Life. 2024 Feb;17(2):217-225. doi: 10.25122/jml-2023-0355. PMID: 38813352; PMCID: PMC11131628. 2: Saklani R, Yadav PK, Tiwari AK, Gawali SL, Hassan PA, Yadav K, Mugale MN, Kalleti N, Rath SK, Mishra DP, Dierking I, Chourasia MK. Synchronized Codelivery of Combination Chemotherapies Intratumorally Using a Lipidic Lyotropic Liquid Crystal System. ACS Appl Mater Interfaces. 2024 Jun 5;16(22):29098-29111. doi: 10.1021/acsami.4c01432. Epub 2024 May 23. PMID: 38780083.
1: Augustyn B, Stepien P, Poojari C, Mobarak E, Polit A, Wisniewska-Becker A, Róg T. Cholesteryl Hemisuccinate Is Not a Good Replacement for Cholesterol in Lipid Nanodiscs. J Phys Chem B. 2019 Nov 21;123(46):9839-9845. doi: 10.1021/acs.jpcb.9b07853. Epub 2019 Nov 12. PMID: 31674185. 2: Kulig W, Tynkkynen J, Javanainen M, Manna M, Rog T, Vattulainen I, Jungwirth P. How well does cholesteryl hemisuccinate mimic cholesterol in saturated phospholipid bilayers? J Mol Model. 2014 Feb;20(2):2121. doi: 10.1007/s00894-014-2121-z. Epub 2014 Feb 14. PMID: 24526383. 3: Luo L, Chen Q, Gong H, Liu L, Zhou L, He H, Zhang Y, Yin T, Tang X. Capacity of cholesteryl hemisuccinate in ion pair/phospholipid complex to improve drug- loading, stability and antibacterial activity of clarithromycin intravenous lipid microsphere. Colloids Surf B Biointerfaces. 2018 Dec 1;172:262-271. doi: 10.1016/j.colsurfb.2018.08.038. Epub 2018 Aug 24. PMID: 30173093. 4: Varshosaz J, Taymouri S, Hassanzadeh F, Javanmard SH, Rostami M. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093. doi: 10.1155/2015/746093. Epub 2015 Mar 8. PMID: 25839040; PMCID: PMC4370104. 5: Ding WX, Qi XR, Li P, Maitani Y, Nagai T. Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d. Int J Pharm. 2005 Aug 26;300(1-2):38-47. doi: 10.1016/j.ijpharm.2005.05.005. PMID: 15978754. 6: Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402):eaas8935. doi: 10.1126/science.aas8935. Epub 2018 Jun 28. PMID: 29954986. 7: Cheng X, Lee RJ. The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery. Adv Drug Deliv Rev. 2016 Apr 1;99(Pt A):129-137. doi: 10.1016/j.addr.2016.01.022. Epub 2016 Feb 18. PMID: 26900977. 8: Hafez IM, Cullis PR. Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior. Biochim Biophys Acta. 2000 Jan 15;1463(1):107-14. doi: 10.1016/s0005-2736(99)00186-8. PMID: 10631299. 9: Domingues N, Estronca LMBB, Silva J, Encarnação MR, Mateus R, Silva D, Santarino IB, Saraiva M, Soares MIL, Pinho E Melo TMVD, Jacinto A, Vaz WLC, Vieira OV. Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):210-220. doi: 10.1016/j.bbalip.2016.10.009. Epub 2016 Oct 26. PMID: 27793708. 10: Kolena J, Kasal A. Effects of cholesteryl esters on the accessibility of LH/hCG receptors and membrane lipid fluidity in rat testes. Biochim Biophys Acta. 1989 Mar 13;979(3):279-86. doi: 10.1016/0005-2736(89)90245-9. PMID: 2923882.