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MedKoo Cat#: 414884 | Name: D –α-Tocopherol acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

D –α-Tocopherol acetate also known as vitamin E acetate, is a more stable form of vitamin E in the form of the ester of acetic acid and α-tocopherol. This product is an oil or semi-solid, ~1360 IU/g

Chemical Structure

D –α-Tocopherol acetate
D –α-Tocopherol acetate
CAS#58-95-7 (acetate)

Theoretical Analysis

MedKoo Cat#: 414884

Name: D –α-Tocopherol acetate

CAS#: 58-95-7 (acetate)

Chemical Formula: C31H52O3

Exact Mass: 472.3916

Molecular Weight: 472.75

Elemental Analysis: C, 78.76; H, 11.09; O, 10.15

Price and Availability

Size Price Availability Quantity
1g USD 150.00 2 Weeks
2g USD 250.00 2 Weeks
5g USD 450.00 2 Weeks
10g USD 650.00 2 Weeks
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Related CAS #
59-02-9 (vitamin E) 58-95-7 (acetate) 17407-37-3 (Hemisuccinate) 4345-03-3(succinate) 9002-96-4 (PEG 1000 succinate) 38976-17-9 (phosphate)
Synonym
D –α-Tocopherol acetate; vitamin E acetate; D –alpha-Tocopherol acetate; alpha-Tocopherol acetate
IUPAC/Chemical Name
(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl acetate
InChi Key
ZAKOWWREFLAJOT-CEFNRUSXSA-N
InChi Code
InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1
SMILES Code
CC(OC1=C(C)C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C2C(C)=C1C)=O
Appearance
oil or semi-solid
Purity
~1360 IU/g
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 472.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Niki E, Traber MG. A history of vitamin E. Ann Nutr Metab. 2012;61(3):207-12. doi: 10.1159/000343106. Epub 2012 Nov 26. PMID: 23183290. 2: Zahid S, Khalid H, Ikram F, Iqbal H, Samie M, Shahzadi L, Shah AT, Yar M, Chaudhry AA, Awan SJ, Khan AF, Rehman IU. Bi-layered α-tocopherol acetate loaded membranes for potential wound healing and skin regeneration. Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:438-447. doi: 10.1016/j.msec.2019.03.080. Epub 2019 Mar 23. PMID: 31029339. 3: Müller HC, van Bibber-Krueger CL, Drouillard JS. Effect of alpha-tocopherol acetate and ascorbic acid on performance, carcass traits, and incidence and severity of liver abscesses in feedlot cattle. J Anim Sci. 2018 Sep 7;96(9):3878-3883. doi: 10.1093/jas/sky231. PMID: 29893877; PMCID: PMC6127816. 4: Jensen SK, Lashkari S, Kristensen NB. Pharmacokinetics of α-tocopherol stereoisomers in plasma and milk of cows following a single dose injection of all-rac-α-tocopheryl acetate. Food Chem. 2020 Apr 25;310:125931. doi: 10.1016/j.foodchem.2019.125931. Epub 2019 Dec 3. PMID: 31835226. 5: Lashkari S, Krogh Jensen S, Bernes G. Biodiscrimination of α-tocopherol stereoisomers in plasma and tissues of lambs fed different proportions of all- rac-α-tocopheryl acetate and RRR-α-tocopheryl acetate1,2. J Anim Sci. 2019 Mar 1;97(3):1222-1233. doi: 10.1093/jas/skz011. PMID: 30624663; PMCID: PMC6396261. 6: Horn M, Gunn P, Van Emon M, Lemenager R, Burgess J, Pyatt NA, Lake SL. Effects of natural (RRR alpha-tocopherol acetate) or synthetic (all-rac alpha- tocopherol acetate) vitamin E supplementation on reproductive efficiency in beef cows. J Anim Sci. 2010 Sep;88(9):3121-7. doi: 10.2527/jas.2009-1807. Epub 2010 May 21. PMID: 20495121. 7: Rey A, Amazan D, Cordero G, Olivares A, López-Bote CJ. Lower Oral Doses of Micellized α-Tocopherol Compared to α-Tocopheryl Acetate in Feed Modify Fatty Acid Profiles and Improve Oxidative Status in Pigs. Int J Vitam Nutr Res. 2014;84(5-6):229-43. doi: 10.1024/0300-9831/a000209. PMID: 26255544. 8: Hymøller L, Lashkari S, Clausen TN, Jensen SK. Distribution of α-tocopherol stereoisomers in mink (Mustela vison) organs varies with the amount of all-rac- α-tocopheryl acetate in the diet. Br J Nutr. 2018 Dec;120(12):1332-1337. doi: 10.1017/S0007114518002878. Epub 2018 Oct 17. PMID: 30328404. 9: Zingg JM. Water-Soluble Vitamin E-Tocopheryl Phosphate. Adv Food Nutr Res. 2018;83:311-363. doi: 10.1016/bs.afnr.2017.12.007. Epub 2018 Feb 12. PMID: 29477225. 10: Horn MJ, Van Emon ML, Gunn PJ, Eicher SD, Lemenager RP, Burgess J, Pyatt N, Lake SL. Effects of maternal natural (RRR alpha-tocopherol acetate) or synthetic (all-rac alpha-tocopherol acetate) vitamin E supplementation on suckling calf performance, colostrum immunoglobulin G, and immune function. J Anim Sci. 2010 Sep;88(9):3128-35. doi: 10.2527/jas.2009-2035. Epub 2010 May 21. PMID: 20495133.