Vitamin E Succinate | CAS# 4345-03-3 | lipid reagent

MedKoo Cat#: 414885 | Name: Vitamin E Succinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vitamin E Succinate, also known as D-α-Tocopherol Succinate, is a weakly acidic derivative of D –α-Tocopherol Hemisuccinate. It acts as an ionizable anionic surfactant and is commonly used to stabilize PE-rich pH-sensitive liposomes. It has been used as a precursor of D –α-Tocopherol for the protection of liver toxicity in an animal model. It was also reported that alpha-tocopheryl succinate has in vivo anti-tumour activity, due to induce apoptosis by causing lysosomal instability.

Chemical Structure

Vitamin E Succinate

CAS#4345-03-3(succinate)

Theoretical Analysis

MedKoo Cat#: 414885

Name: Vitamin E Succinate

CAS#: 4345-03-3(succinate)

Chemical Formula: C33H54O5

Exact Mass: 530.3971

Molecular Weight: 530.79

Elemental Analysis: C, 74.67; H, 10.25; O, 15.07

Price and Availability

Size	Price	Availability
50mg	USD 90.00	Ready to ship
100mg	USD 150.00	Ready to ship
200mg	USD 250.00	Ready to ship
500mg	USD 450.00	Ready to ship
1g	USD 750.00	Ready to ship
2g	USD 1,050.00	Ready to ship
5g	USD 1,950.00	2 weeks
10g	USD 2,950.00	2 weeks

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Related CAS #

59-02-9 (vitamin E) 58-95-7 (acetate) 17407-37-3 (Hemisuccinate) 4345-03-3(succinate) 9002-96-4 (PEG 1000 succinate) 38976-17-9 (phosphate)

Synonym

D –α-Tocopherol Hemisuccinate; Vitamin E Succinate; Tocopherol succinate; D-α-Tocopherol Succinate; D-alpha-Tocopherol Succinate; alpha-Tocopherol Succinate

IUPAC/Chemical Name

4-oxo-4-(((R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl)oxy)butanoic acid

InChi Key

IELOKBJPULMYRW-NJQVLOCASA-N

InChi Code

InChI=1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1

SMILES Code

CC1=C2C(=C(C)C(OC(CCC(O)=O)=O)=C1C)CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

[Hiroaki Jizomoto *, Eri Kanaoka, Koichiro Hirano, pH-Sensitive liposomes composed of tocopherol hemisuccinate and of phosphatidylethanolamine including tocopherol hemisuccinate. Biochimica et Biophysics Acta 1213 (1994) 343-348] [Tirmenstein, M.A., Leraas, T.L., Fariss, M.W., 1997. alpha-Tocopheryl hemisuccinate administration increases rat liver subcellular alpha-tocopherol levels and protects against carbon tetrachloride-induced hepatotoxicity. Toxicol. Lett. 92, 67–77] . [Neuzil J, Zhao M, Ostermann G, Sticha M, Gellert N, Weber C, et al. Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem J 2002; 362 (Pt 3):709–715]

Certificate of Analysis

View CoA: current batch, Lot#T23C09I12

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 530.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Mass Spectrometric Based Metabolomics of the Saudi Cultivar of Fenugreek (Trigonella foenum-graecum L.): A Combined GC-MS, Antimicrobial and Computational Approach. Pharmaceuticals (Basel). 2024 Dec 21;17(12):1733. doi: 10.3390/ph17121733. PMID: 39770575; PMCID: PMC11677947. 10: Mohamed N, Ahmed Abukhadir SS, Syed Hashim SA, Adnan NS, Aziz MA, Muhammad N. Vitamin E Improves Cellular and Structural Bone Histomorphometry in an Alcohol-Induced Osteoporosis Rat Model. Pharmaceuticals (Basel). 2024 Dec 20;17(12):1730. doi: 10.3390/ph17121730. PMID: 39770572; PMCID: PMC11677299. 11: Thbayh DK, Mentes D, Boros ZR, Palusiak M, Farkas L, Viskolcz B, Fiser B. α-Tocopherol and Trolox as Effective Natural Additives for Polyurethane Foams: A DFT and Experimental Study. Molecules. 2024 Dec 21;29(24):6037. doi: 10.3390/molecules29246037. PMID: 39770125; PMCID: PMC11678614. 12: Bottegal DN, Álvarez-Rodríguez J, Latorre MÁ, Lobón S. Dietary Inclusion of Carob Pulp (Ceratonia siliqua L.) 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Enzymatic Interesterification of Cold-Pressed Maqui (Aristotelia chilensis (Mol.) Stuntz) Seed Oil and Belly Oil from Rainbow Trout (Oncorhynchus mykiss) Through Supercritical CO2. Mar Drugs. 2024 Dec 4;22(12):547. doi: 10.3390/md22120547. PMID: 39728122; PMCID: PMC11678877. 19: Gülen S, Günal-Köroğlu D, Turan S. Effects of cold-pressed oil additives in varying proportions: Physico-chemical characteristics of mayonnaises. Food Chem. 2024 Dec 18;469:142576. doi: 10.1016/j.foodchem.2024.142576. Epub ahead of print. PMID: 39724701. 20: Quradha MM, Tamfu AN, Duru ME, Kucukaydin S, Iqbal M, Qahtan AMF, Khan R, Ceylan O. Evaluation of HPLC Profile, Antioxidant, Quorum Sensing, Biofilm, Swarming Motility, and Enzyme Inhibition Activities of Conventional and Green Extracts of Salvia triloba. Food Sci Nutr. 2024 Nov 24;12(12):10716-10733. doi: 10.1002/fsn3.4580. PMID: 39723056; PMCID: PMC11666897.